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    phb2 prohibitin Phb2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538888, updated on 18-Sep-2024

    Summary

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    Official Symbol
    phb2
    Official Full Name
    prohibitin Phb2
    Primary source
    PomBase:SPCC1322.16
    Locus tag
    SPOM_SPCC1322.16
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See phb2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003421.2 (1323827..1325076)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ribosome quality control complex subunit Rqc2 Neighboring gene ncRNA Neighboring gene histone deacetylase, Sirtuin family, NAD-dependent Hst2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dysfunction of Prohibitin 2 Results in Reduced Susceptibility to Multiple Antifungal Drugs via Activation of the Oxidative Stress-Responsive Transcription Factor Pap1 in Fission Yeast. Liu Q, et al. Antimicrob Agents Chemother, 2018 Nov. PMID 30181366, Free PMC Article
    2. Prohibitins, Phb1 and Phb2, function as Atg8 receptors to support yeast mitophagy and also play a negative regulatory role in Atg32 processing. García-Chávez D, et al. Autophagy, 2024 Nov. PMID 38964378,
    3. SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast. Singh NS, et al. Curr Biol, 2011 Dec 6. PMID 22119525, Free PMC Article
    4. Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex. Egan ED, et al. RNA, 2014 Jun. PMID 24713849, Free PMC Article
    5. A central role for TOR signalling in a yeast model for juvenile CLN3 disease. Bond ME, et al. Microb Cell, 2015 Nov 11. PMID 28357272, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables mitochondrion autophagosome adaptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitophagy TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prohibitin Phb2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1323827..1325076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023134.3 → NP_588144.2  prohibitin Phb2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588144.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94550
      Conserved Domains (2) summary
      smart00244
      Location:44 → 205
      PHB; prohibitin homologues
      cd03401
      Location:45 → 239
      SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    Nucleotide Protein
    Heading Accession and Version

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