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    hus5 small ubiquitin-like modifier-conjugating enzyme Hus5 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542196, updated on 18-Sep-2024

    Summary

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    Official Symbol
    hus5
    Official Full Name
    small ubiquitin-like modifier-conjugating enzyme Hus5
    Primary source
    PomBase:SPAC30D11.13
    Locus tag
    SPOM_SPAC30D11.13
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    ubc9
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    Genomic context

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    See hus5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003424.3 (1094262..1095474, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Moeb/ThiF domain-containing protein Neighboring gene RNA-binding protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Ser Neighboring gene tRNA-Met Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular mimicry of SUMO promotes DNA repair. Prudden J, et al. Nat Struct Mol Biol, 2009 May. PMID 19363481, Free PMC Article
    2. SUMO modification is involved in the maintenance of heterochromatin stability in fission yeast. Shin JA, et al. Mol Cell, 2005 Sep 16. PMID 16168376
    3. Characterization of SUMO-conjugating enzyme mutants in Schizosaccharomyces pombe identifies a dominant-negative allele that severely reduces SUMO conjugation. Ho JC, et al. Biochem J, 2003 May 15. PMID 12597774, Free PMC Article
    4. Role of the fission yeast SUMO E3 ligase Pli1p in centromere and telomere maintenance. Xhemalce B, et al. EMBO J, 2004 Oct 1. PMID 15359282, Free PMC Article
    5. The Schizosaccharomyces pombe hus5 gene encodes a ubiquitin conjugating enzyme required for normal mitosis. al-Khodairy F, et al. J Cell Sci, 1995 Feb. PMID 7768995

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IC
    Inferred by Curator
    more info
    		  
    enables SUMO activating enzyme activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables SUMO conjugating enzyme activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables SUMO conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein sumoylation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein sumoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    small ubiquitin-like modifier-conjugating enzyme Hus5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1094262..1095474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018600.3 → NP_593204.1  small ubiquitin-like modifier-conjugating enzyme Hus5 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593204.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P40984
      Conserved Domains (2) summary
      COG5078
      Location:1 → 156
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00179
      Location:8 → 152
      UQ_con; Ubiquitin-conjugating enzyme
    Nucleotide Protein
    Heading Accession and Version

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