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    amk2 serine/threonine protein kinase AMPK (beta) regulatory subunit Amk2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539130, updated on 18-Sep-2024

    Summary

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    Official Symbol
    amk2
    Official Full Name
    serine/threonine protein kinase AMPK (beta) regulatory subunit Amk2
    Primary source
    PomBase:SPCC1919.03c
    Locus tag
    SPOM_SPCC1919.03C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See amk2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003421.2 (2207485..2209027, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin-dependent (CaMKK) protein kinase kinase Ckk2/Ppk34 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GPI synthesis protein pig-X Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural insight into AMPK regulation: ADP comes into play. Jin X, et al. Structure, 2007 Oct. PMID 17937917
    2. Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase. Townley R, et al. Science, 2007 Mar 23. PMID 17289942
    3. Genetic-interaction screens uncover novel biological roles and regulators of transcription factors in fission yeast. Chatfield-Reed K, et al. G3 (Bethesda), 2022 Aug 25. PMID 35924983, Free PMC Article
    4. AMPK phosphorylation by Ssp1 is required for proper sexual differentiation in fission yeast. Valbuena N, et al. J Cell Sci, 2012 Jun 1. PMID 22375066
    5. A chaperone-assisted degradation pathway targets kinetochore proteins to ensure genome stability. Kriegenburg F, et al. PLoS Genet, 2014 Jan. PMID 24497846, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CAMKK-AMPK signaling cascade IC
    Inferred by Curator
    more info
    		  
    involved_in induction of conjugation with cellular fusion EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in positive regulation of flocculation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    part_of nucleotide-activated protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleotide-activated protein kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine protein kinase AMPK (beta) regulatory subunit Amk2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      2207485..2209027 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023476.3 → NP_588485.1  serine/threonine protein kinase AMPK (beta) regulatory subunit Amk2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588485.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P78789, Q1L851, Q9UU43
      Conserved Domains (2) summary
      smart01010
      Location:202 → 294
      AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
      pfam16561
      Location:100 → 180
      AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase
    Nucleotide Protein
    Heading Accession and Version

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