ptr8 transcription factor TFIIH complex ERCC-3 subunit Ptr8 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Official Symbol: ptr8
Official Full Name: transcription factor TFIIH complex ERCC-3 subunit Ptr8
Primary source: PomBase:SPAC17A5.06
Locus tag: SPOM_SPAC17A5.06
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as: ercc3
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Genomic context

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See ptr8 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_003424.3 (1761547..1764319)

Chromosome I - NC_003424.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The XPB helicase, a TFIIH subunit, acts as an ATP-driven motor to reorganize the tightly wrapped multiprotein eukaryotic preinitiation complex during the remodeling that precedes elongation and the coupling to RNA processing events. [XPB]
Title: TFIIH XPB mutants suggest a unified bacterial-like mechanism for promoter opening but not escape.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables 3'-5' DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	ISM Inferred from Sequence Model more info
enables DNA binding	IC Inferred by Curator more info
enables RNA polymerase II general transcription initiation factor activity	EXP Inferred from Experiment more info	PubMed
enables RNA polymerase II general transcription initiation factor activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in transcription initiation at RNA polymerase II promoter	EXP Inferred from Experiment more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription-coupled nucleotide-excision repair	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
part_of nucleotide-excision repair factor 3 complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	HDA more info	PubMed
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIH core complex	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFIIH holo complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcription factor TFIIH complex ERCC-3 subunit Ptr8

NP_593474.1

transcription factor TFIIH complex DNA helicase (human ERCC3) subunit Ptr8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003424.3 Reference assembly

Range

1761547..1764319

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001018907.3 → NP_593474.1 transcription factor TFIIH complex ERCC-3 subunit Ptr8 [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_593474.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

O13768, Q9US81

Conserved Domains (4) summary

TIGR00603
Location:75 → 797

rad25; DNA repair helicase rad25

pfam04851
Location:323 → 481

ResIII; Type III restriction enzyme, res subunit

pfam13625
Location:91 → 214

Helicase_C_3; Helicase conserved C-terminal domain

pfam16203
Location:505 → 740

ERCC3_RAD25_C; ERCC3/RAD25/XPB C-terminal helicase