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    cdc48 AAA family ATPase involved in ubiquitin-mediated protein degradation Cdc48 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542744, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cdc48
    Official Full Name
    AAA family ATPase involved in ubiquitin-mediated protein degradation Cdc48
    Primary source
    PomBase:SPAC1565.08
    Locus tag
    SPOM_SPAC1565.08
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    dsc6; SPAC6F12.01
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    Genomic context

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    See cdc48 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (1306445..1309266)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene cullin-associated NEDD8-dissociated protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA-binding transcription factor, glucose starvation sensing, Rst2 Neighboring gene ncRNA Neighboring gene SNARE Stx8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling. van den Boom J, et al. Mol Cell, 2018 Jan 18. PMID 29153394
    2. Single site suppressors of a fission yeast temperature-sensitive mutant in cdc48 identified by whole genome sequencing. Marinova IN, et al. PLoS One, 2015. PMID 25658828, Free PMC Article
    3. Lub1 participates in ubiquitin homeostasis and stress response via maintenance of cellular ubiquitin contents in fission yeast. Ogiso Y, et al. Mol Cell Biol, 2004 Mar. PMID 14993272, Free PMC Article
    4. Proximity-dependent biotin labelling in yeast using the engineered ascorbate peroxidase APEX2. Hwang J, et al. Biochem J, 2016 Aug 15. PMID 27274088, Free PMC Article
    5. Int6 and Moe1 interact with Cdc48 to regulate ERAD and proper chromosome segregation. Otero JH, et al. Cell Cycle, 2010 Jan 1. PMID 20016281, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that cdc48 cofactor ufd1 is required for SREBP1/2 cleavage/activation but does not interact with cdc48-rbd2 complex; cdc48-ufd1 is instead required at step prior to rbd2 function, during Golgi localization of dsc1-E3 ligase. (cdc48 = AAA family ATPase cdc48; ufd1 = cdc48-ufd1-npl4 complex component ufd1; dsc1-E3 ligase = ubiquitin-protein ligase E3; SREBP1/2 = sterol regulatory element binding proteins 1/2)
      Title: Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast.
    2. Data show that cell cycle protein Cdc48-353 mutant is structurally compromized at the restrictive temperature.
      Title: Single site suppressors of a fission yeast temperature-sensitive mutant in cdc48 identified by whole genome sequencing.
    3. a new signaling mechanism involving dual recruitment by SUMO and ubiquitin for Cdc48-Ufd1-Npl4 functions in maintaining genome stability.
      Title: Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.
    4. Results suggest that Cdc48, Yin6 and Moe1 act in the same protein complex to concertedly control ERAD and chromosome segregation.
      Title: Int6 and Moe1 interact with Cdc48 to regulate ERAD and proper chromosome segregation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent protein disaggregase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SREBP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inner nuclear membrane-associated protein degradation pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde protein transport, ER to cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cdc48p-Npl4p-Vms1p AAA ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Hrd1p ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RQC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of VCP-NPL4-UFD1 AAA ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic side of mitochondrial outer membrane IC
    Inferred by Curator
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AAA family ATPase involved in ubiquitin-mediated protein degradation Cdc48

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1306445..1309266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018717.3 → NP_593287.3  AAA family ATPase involved in ubiquitin-mediated protein degradation Cdc48 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14221, Q9P3A7
      UniProtKB/TrEMBL
      A0AAN2HE97
    Nucleotide Protein
    Heading Accession and Version

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