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    tas3 RITS complex subunit 3 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540735, updated on 18-Sep-2024

    Summary

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    Official Symbol
    tas3
    Official Full Name
    RITS complex subunit 3
    Primary source
    PomBase:SPBC83.03c
    Locus tag
    SPOM_SPBC83.03C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See tas3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (1514006..1516179, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene UBA/EH/EF hand domain protein Ucp8 Neighboring gene 60S ribosomal protein eL43 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene anaphase-promoting complex platform subcomplex scaffold subunit Apc15

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An alpha motif at Tas3 C terminus mediates RITS cis spreading and promotes heterochromatic gene silencing. Li H, et al. Mol Cell, 2009 Apr 24. PMID 19394293, Free PMC Article
    2. RNA interference (RNAi)-dependent and RNAi-independent association of the Chp1 chromodomain protein with distinct heterochromatic loci in fission yeast. Petrie VJ, et al. Mol Cell Biol, 2005 Mar. PMID 15743828, Free PMC Article
    3. Ablation of RNA interference and retrotransposons accompany acquisition and evolution of transposases to heterochromatin protein CENPB. Upadhyay U, et al. Mol Biol Cell, 2017 Apr 15. PMID 28228545, Free PMC Article
    4. Chp1-Tas3 interaction is required to recruit RITS to fission yeast centromeres and for maintenance of centromeric heterochromatin. Debeauchamp JL, et al. Mol Cell Biol, 2008 Apr. PMID 18212052, Free PMC Article
    5. H3K9 methylation extends across natural boundaries of heterochromatin in the absence of an HP1 protein. Stunnenberg R, et al. EMBO J, 2015 Nov 12. PMID 26438724, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Chp1-Tas3 complex provides a solid and versatile platform to recruit both RNAi-dependent and RNAi-independent gene-silencing pathways for locus-specific regulation of heterochromatin.
      Title: The Chp1-Tas3 core is a multifunctional platform critical for gene silencing by RITS.
    2. Tas3 self-association is required for RNA-induced transcriptional silencing (RITS)spreading and efficient heterochromatic gene silencing at centromeric repeat regions.
      Title: An alpha motif at Tas3 C terminus mediates RITS cis spreading and promotes heterochromatic gene silencing.
    3. findings suggest a pivotal role for Chp1 and its association with Tas3 for the recruitment of RITS, RDRC, and histone H3 K9 methyltransferase activity to centromeres
      Title: Chp1-Tas3 interaction is required to recruit RITS to fission yeast centromeres and for maintenance of centromeric heterochromatin.
    4. Results describe a repetitive motif within Tas3, termed the 'Argonaute hook', that is conserved from yeast to humans and binds Ago1 and 2 through their PIWI domains in vitro and in vivo.
      Title: A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain.
    5. Tas3 interacts with Chp1 through the C-terminal domain of Chp1, and this interaction is necessary for Tas3 stability.
      Title: RNA interference (RNAi)-dependent and RNAi-independent association of the Chp1 chromodomain protein with distinct heterochromatic loci in fission yeast.
    6. Tas3 subunit of the RNAi effector complex RITS. Specifically localizes to centromeric repeats.
      Title: Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs.
    7. Member of the RITS (RNA-induced initiation of transcriptional gene silencing) complex, which is required for RNAi-mediated heterochromatin assembly. [Tas3]
      Title: RNAi-mediated targeting of heterochromatin by the RITS complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables molecular adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables siRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pericentric heterochromatin formation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in siRNA-mediated pericentric heterochromatin formation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in siRNA-mediated pericentric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in silent mating-type cassette heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in silent mating-type cassette heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RITS complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of RITS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mating-type region heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in subtelomeric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RITS complex subunit 3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1514006..1516179 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021529.3 → NP_595635.1  RITS complex subunit 3 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595635.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94687
      Conserved Domains (1) summary
      pfam10427
      Location:117 → 324
      Ago_hook; Argonaute hook
    Nucleotide Protein
    Heading Accession and Version

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