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    hac1 2-hydroxyacyl-CoA lyase Hac1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541142, updated on 18-Sep-2024

    Summary

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    Official Symbol
    hac1
    Official Full Name
    2-hydroxyacyl-CoA lyase Hac1
    Primary source
    PomBase:SPBC725.04
    Locus tag
    SPOM_SPBC725.04
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See hac1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (1208675..1210856)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene pyridoxamine 5'-phosphate oxidase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene nucleotide pyrophosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phytosphingosine degradation pathway includes fatty acid α-oxidation reactions in the endoplasmic reticulum. Kitamura T, et al. Proc Natl Acad Sci U S A, 2017 Mar 28. PMID 28289220, Free PMC Article
    2. Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways. Das J, et al. Sci Signal, 2013 May 21. PMID 23695164, Free PMC Article
    3. Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex. Stewart EV, et al. Mol Cell, 2011 Apr 22. PMID 21504829, Free PMC Article
    4. A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human. Vo TV, et al. Cell, 2016 Jan 14. PMID 26771498, Free PMC Article
    5. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 2-hydroxyacyl-CoA lyase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine pyrophosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid alpha-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in peroxisomal matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    2-hydroxyacyl-CoA lyase Hac1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1208675..1210856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021395.3 → NP_595484.1  2-hydroxyacyl-CoA lyase Hac1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595484.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9Y7M1
      Conserved Domains (4) summary
      cd07035
      Location:7 → 161
      TPP_PYR_POX_like; Pyrimidine (PYR) binding domain of POX and related proteins
      PRK09259
      Location:8 → 550
      PRK09259; putative oxalyl-CoA decarboxylase; Validated
      cd02004
      Location:367 → 547
      TPP_BZL_OCoD_HPCL; Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL ...
      pfam00205
      Location:192 → 322
      TPP_enzyme_M; Thiamine pyrophosphate enzyme, central domain
    Nucleotide Protein
    Heading Accession and Version

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