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    bfr1 plasma membrane brefeldin A efflux transporter Bfr1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539195, updated on 18-Sep-2024

    Summary

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    Official Symbol
    bfr1
    Official Full Name
    plasma membrane brefeldin A efflux transporter Bfr1
    Primary source
    PomBase:SPCC18B5.01c
    Locus tag
    SPOM_SPCC18B5.01C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    hba2; SPCPJ732.04c
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    Genomic context

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    See bfr1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (709302..715418, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein meu15 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe. Akiyama K, et al. J Toxicol Sci, 2011 Jan. PMID 21297349
    2. Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome. Arita Y, et al. Mol Biosyst, 2011 May. PMID 21340088
    3. Genome-wide screen of genes required for caffeine tolerance in fission yeast. Calvo IA, et al. PLoS One, 2009 Aug 12. PMID 19672306, Free PMC Article
    4. Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology. Kawashima SA, et al. Chem Biol, 2012 Jul 27. PMID 22840777, Free PMC Article
    5. A survey of all 11 ABC transporters in fission yeast: two novel ABC transporters are required for red pigment accumulation in a Schizosaccharomyces pombe adenine biosynthetic mutant. Iwaki T, et al. Microbiology (Reading), 2006 Aug. PMID 16849797

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. It is responsible for tributyltin resistance in Schizosaccharomyces pombe.
      Title: Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    plasma membrane brefeldin A efflux transporter Bfr1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      709302..715418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022923.4 → NP_587932.3  plasma membrane brefeldin A efflux transporter Bfr1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_587932.3

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O00035, P41820, P87254, Q09194, Q9C0U4, Q9USL8
      Conserved Domains (6) summary
      cd03232
      Location:879 → 1107
      ABCG_PDR_domain2; Second domain of the pleiotropic drug resistance-like (PDR) subfamily G of ATP-binding cassette transporters
      cd03233
      Location:166 → 392
      ABCG_PDR_domain1; First domain of the pleiotropic drug resistance-like subfamily G of ATP-binding cassette transporters
      TIGR00956
      Location:108 → 1516
      3a01205; Pleiotropic Drug Resistance (PDR) Family protein
      pfam01061
      Location:526 → 729
      ABC2_membrane; ABC-2 type transporter
      pfam06422
      Location:741 → 835
      PDR_CDR; CDR ABC transporter
      pfam14510
      Location:102 → 160
      ABC_trans_N; ABC-transporter extracellular N-terminal
    Nucleotide Protein
    Heading Accession and Version

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