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    brl2 histone H2B-K119 ubiquitin ligase complex (HULC) subunit, ubiquitin-protein ligase E3 Brl2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539307, updated on 18-Sep-2024

    Summary

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    Official Symbol
    brl2
    Official Full Name
    histone H2B-K119 ubiquitin ligase complex (HULC) subunit, ubiquitin-protein ligase E3 Brl2
    Primary source
    PomBase:SPCC970.10c
    Locus tag
    SPOM_SPCC970.10C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    rfp1
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    Genomic context

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    See brl2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003421.2 (489781..493167)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene wtf antidote-like meiotic drive suppressor Wtf9 Neighboring gene exocyst complex subunit Exo4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene inositol polyphosphate kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation. Tanny JC, et al. Genes Dev, 2007 Apr 1. PMID 17374714, Free PMC Article
    2. The absence of histone H2B monoubiquitination in the Arabidopsis hub1 (rdo4) mutant reveals a role for chromatin remodeling in seed dormancy. Liu Y, et al. Plant Cell, 2007 Feb. PMID 17329563, Free PMC Article
    3. New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe. Maki T, et al. PLoS Genet, 2018 May. PMID 29852001, Free PMC Article
    4. HULC, a histone H2B ubiquitinating complex, modulates heterochromatin independent of histone methylation in fission yeast. Zofall M, et al. J Biol Chem, 2007 May 11. PMID 17363370
    5. Cdk9 and H2Bub1 signal to Clr6-CII/Rpd3S to suppress aberrant antisense transcription. Sansó M, et al. Nucleic Acids Res, 2020 Jul 27. PMID 32496538, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables histone H2B C-terminal K residue ubiquitin ligase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		  
    Process Evidence Code Pubs
    involved_in donor selection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in epigenetic regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription elongation-coupled chromatin remodeling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of HULC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of HULC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    histone H2B-K119 ubiquitin ligase complex (HULC) subunit, ubiquitin-protein ligase E3 Brl2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      489781..493167
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022838.3 → NP_587845.1  histone H2B-K119 ubiquitin ligase complex (HULC) subunit, ubiquitin-protein ligase E3 Brl2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_587845.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74563
      Conserved Domains (2) summary
      smart00184
      Location:627 → 666
      RING; Ring finger
      pfam08647
      Location:433 → 525
      BRE1; BRE1 E3 ubiquitin ligase
    Nucleotide Protein
    Heading Accession and Version

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