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    CMC2 Cmc2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852220, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CMC2
    Official Full Name
    Cmc2p
    Primary source
    SGD:S000007488
    Locus tag
    YBL059C-A
    See related
    AllianceGenome:SGD:S000007488; FungiDB:YBL059C-A; VEuPathDB:YBL059C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable metal ion binding activity. Involved in mitochondrial respiratory chain complex assembly. Located in mitochondrial intermembrane space. Orthologous to human CMC2 (C-X9-C motif containing 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CMC2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_001134.8 (110125..110539, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Skt5p Neighboring gene Arf family guanine nucleotide exchange factor YEL1 Neighboring gene Iai11p Neighboring gene protein phosphatase regulator SHP1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The conserved mitochondrial twin Cx9C protein Cmc2 Is a Cmc1 homologue essential for cytochrome c oxidase biogenesis. Horn D, et al. J Biol Chem, 2010 May 14. PMID 20220131, Free PMC Article
    2. Cmc1p is a conserved mitochondrial twin CX9C protein involved in cytochrome c oxidase biogenesis. Horn D, et al. Mol Cell Biol, 2008 Jul. PMID 18443040, Free PMC Article
    3. Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathway. Gabriel K, et al. J Mol Biol, 2007 Jan 19. PMID 17095012
    4. Systematic analysis of the twin cx(9)c protein family. Longen S, et al. J Mol Biol, 2009 Oct 23. PMID 19703468
    5. ATP synthase interactome analysis identifies a new subunit l as a modulator of permeability transition pore in yeast. Panja C, et al. Sci Rep, 2023 Mar 7. PMID 36882574, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that Cmc1p could play a direct or indirect role in copper trafficking and distribution to COX and Sod1p.
      Title: Cmc1p is a conserved mitochondrial twin CX9C protein involved in cytochrome c oxidase biogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Cmc2p
    NP_031358.1
    • Protein involved in respiratory chain complex assembly or maintenance; protein of the mitochondrial intermembrane space; contains twin Cx9C motifs that can form coiled coil-helix-coiled-coil helix fold

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      110125..110539 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184440.1 → NP_031358.1  TPA: Cmc2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_031358.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPU0, Q3E7A4
      UniProtKB/TrEMBL
      A6ZKN9, B3LNJ5, C8Z3N8, G2W8U9, N1PAX1
      Conserved Domains (1) summary
      pfam08583
      Location:1 → 70
      Cmc1; Cytochrome c oxidase biogenesis protein Cmc1 like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3E7A4.1

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