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    bit61 Protor homolog, Bit61 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538963, updated on 18-Sep-2024

    Summary

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    Official Symbol
    bit61
    Official Full Name
    Protor homolog, Bit61
    Primary source
    PomBase:SPCC777.08c
    Locus tag
    SPOM_SPCC777.08C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See bit61 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (1611047..1612763, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene alpha-1,2-mannosyltransferase Omh3 Neighboring gene acetylornithine aminotransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NEDD8-conjugating enzyme Ubc12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rab small GTPase emerges as a regulator of TOR complex 2. Tatebe H, et al. Small GTPases, 2010 Nov. PMID 21625337, Free PMC Article
    2. The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe. Ikai N, et al. Open Biol, 2011 Nov. PMID 22645648, Free PMC Article
    3. Rab-family GTPase regulates TOR complex 2 signaling in fission yeast. Tatebe H, et al. Curr Biol, 2010 Nov 23. PMID 21035342, Free PMC Article
    4. Glucose activates TORC2-Gad8 protein via positive regulation of the cAMP/cAMP-dependent protein kinase A (PKA) pathway and negative regulation of the Pmk1 protein-mitogen-activated protein kinase pathway. Cohen A, et al. J Biol Chem, 2014 Aug 1. PMID 24928510, Free PMC Article
    5. Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits. Hayashi T, et al. Genes Cells, 2007 Dec. PMID 18076573

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our work reveals that SAGA is a direct target of nutrient-sensing pathways and has uncovered a mechanism by which TORC1 and TORC2 converge to control gene expression and cell fate decisions.
      Title: TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.
    2. findings highlight the significance of glucose availability in regulation of TORC2-Gad8 and indicate a novel link between the cAMP/PKA, Pmk1/MAPK, and TORC2-Gad8 signaling
      Title: Glucose activates TORC2-Gad8 protein via positive regulation of the cAMP/cAMP-dependent protein kinase A (PKA) pathway and negative regulation of the Pmk1 protein-mitogen-activated protein kinase pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein kinase regulator activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in TORC2 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in TORC2 signaling IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TORC2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Protor homolog, Bit61

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1611047..1612763 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023244.3 → NP_588254.1  Protor homolog, Bit61 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588254.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74547
      Conserved Domains (1) summary
      pfam08539
      Location:214 → 365
      HbrB; HbrB-like
    Nucleotide Protein
    Heading Accession and Version

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