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    ccr4 CCR4-Not complex subunit Ccr4 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538913, updated on 14-Nov-2024

    Summary

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    Official Symbol
    ccr4
    Official Full Name
    CCR4-Not complex subunit Ccr4
    Primary source
    PomBase:SPCC31H12.08c
    Locus tag
    SPOM_SPCC31H12.08C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    not6; SPCC5E4.02c
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    Genomic context

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    See ccr4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (637435..639623, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein mug111 Neighboring gene ncRNA Neighboring gene COPII cargo receptor subunit Sec23a Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene transcription initiation factor TFIID subunit 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Iron homeostasis regulates facultative heterochromatin assembly in adaptive genome control. Gallagher PS, et al. Nat Struct Mol Biol, 2018 May. PMID 29686279, Free PMC Article
    2. Involvement of fission yeast Pdc2 in RNA degradation and P-body function. Wang CY, et al. RNA, 2017 Apr. PMID 28031482, Free PMC Article
    3. The architecture of the Schizosaccharomyces pombe CCR4-NOT complex. Ukleja M, et al. Nat Commun, 2016 Jan 25. PMID 26804377, Free PMC Article
    4. RNA-binding proteins distinguish between similar sequence motifs to promote targeted deadenylation by Ccr4-Not. Webster MW, et al. Elife, 2019 Jan 2. PMID 30601114, Free PMC Article
    5. mRNA Deadenylation Is Coupled to Translation Rates by the Differential Activities of Ccr4-Not Nucleases. Webster MW, et al. Mol Cell, 2018 Jun 21. PMID 29932902, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Findings reveal a coupling between the rates of translation and deadenylation that is dependent on Pab1 and Ccr4-Not.
      Title: mRNA Deadenylation Is Coupled to Translation Rates by the Differential Activities of Ccr4-Not Nucleases.
    2. The molecular architecture of the CCR4-NOT complex suggests that the nuclease module is located near the S. pombe-specific subunit Mmi1.
      Title: The architecture of the Schizosaccharomyces pombe CCR4-NOT complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    contributes_to 3'-5'-RNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables poly(A)-specific ribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of CCR4-NOT core complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    CCR4-Not complex subunit Ccr4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      637435..639623 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022893.3 → NP_587901.1  CCR4-Not complex subunit Ccr4 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_587901.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74874
      Conserved Domains (4) summary
      cd09097
      Location:338 → 673
      Deadenylase_CCR4; C-terminal deadenylase domain of CCR4 and related domains
      sd00033
      Location:163 → 182
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:183 → 221
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:183 → 239
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version

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