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    ade6 phosphoribosylaminoimidazole carboxylase Ade6 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538734, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ade6
    Official Full Name
    phosphoribosylaminoimidazole carboxylase Ade6
    Primary source
    PomBase:SPCC1322.13
    Locus tag
    SPOM_SPCC1322.13
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    min1
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    Genomic context

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    See ade6 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (1316281..1318035)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene mitotic spindle checkpoint kinase Bub1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene transporter chaperone complex subunit vtc4 Neighboring gene ncRNA Neighboring gene 60S ribosomal protein L34

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA sequence analysis of the ade6 gene of Schizosaccharomyces pombe. Wild-type and mutant alleles including the recombination host spot allele ade6-M26. Szankasi P, et al. J Mol Biol, 1988 Dec 20. PMID 3221399
    2. Nonsense codon suppression in fission yeast due to mutations of tRNA(Ser.11) and translation release factor Sup35 (eRF3). Protacio RU, et al. Curr Genet, 2015 May. PMID 25519804, Free PMC Article
    3. apd1+, a gene required for red pigment formation in ade6 mutants of Schizosaccharomyces pombe, encodes an enzyme required for glutathione biosynthesis: a role for glutathione and a glutathione-conjugate pump. Chaudhuri B, et al. Genetics, 1997 Jan. PMID 9017391, Free PMC Article
    4. Purine biosynthetic genes are required for cadmium tolerance in Schizosaccharomyces pombe. Speiser DM, et al. Mol Cell Biol, 1992 Dec. PMID 1448066, Free PMC Article
    5. Role of the Tsc1-Tsc2 complex in signaling and transport across the cell membrane in the fission yeast Schizosaccharomyces pombe. Matsumoto S, et al. Genetics, 2002 Jul. PMID 12136010, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylaminoimidazole carboxylase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' IMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in purine nucleobase biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    phosphoribosylaminoimidazole carboxylase Ade6

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1316281..1318035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023131.3 → NP_588141.1  phosphoribosylaminoimidazole carboxylase Ade6 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588141.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P15567
      Conserved Domains (3) summary
      PLN02948
      Location:6 → 550
      PLN02948; phosphoribosylaminoimidazole carboxylase
      COG0041
      Location:385 → 545
      PurE; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]
      pfam02222
      Location:112 → 281
      ATP-grasp; ATP-grasp domain
    Nucleotide Protein
    Heading Accession and Version

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