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    arc3 ARP2/3 actin-organizing complex subunit Arc21 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540144, updated on 18-Sep-2024

    Summary

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    Official Symbol
    arc3
    Official Full Name
    ARP2/3 actin-organizing complex subunit Arc21
    Primary source
    PomBase:SPBC1778.08c
    Locus tag
    SPOM_SPBC1778.08C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    arc18; arc21
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    Genomic context

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    See arc3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003423.3 (3111115..3112237, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene fimbrin Neighboring gene ncRNA Neighboring gene carnosine N-methyltransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GTPase-activating protein Neighboring gene ncRNA Neighboring gene serine/threonine protein kinase Ppk21/Pdk1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Schizosaccharomyces pombe Arc3 is a conserved subunit of the Arp2/3 complex required for polarity, actin organization, and endocytosis. Cabrera R, et al. Yeast, 2011 Jun. PMID 21449051, Free PMC Article
    2. Conformational changes in Arp2/3 complex induced by ATP, WASp-VCA, and actin filaments. Espinoza-Sanchez S, et al. Proc Natl Acad Sci U S A, 2018 Sep 11. PMID 30150414, Free PMC Article
    3. A mutant of Arp2p causes partial disassembly of the Arp2/3 complex and loss of cortical actin function in fission yeast. Morrell JL, et al. Mol Biol Cell, 1999 Dec. PMID 10588653, Free PMC Article
    4. Cryo-EM structures reveal how phosphate release from Arp3 weakens actin filament branches formed by Arp2/3 complex. Chavali SS, et al. Nat Commun, 2024 Mar 6. PMID 38448439, Free PMC Article
    5. Structure and biochemical properties of fission yeast Arp2/3 complex lacking the Arp2 subunit. Nolen BJ, et al. J Biol Chem, 2008 Sep 26. PMID 18640983, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data suggest that Arc3p is an evolutionarily conserved subunit of the Arp2/3 complex required for proper F-actin organization and efficient endocytosis.
      Title: Schizosaccharomyces pombe Arc3 is a conserved subunit of the Arp2/3 complex required for polarity, actin organization, and endocytosis.
    2. These data suggest that proteasomes display Arc3-dependent mobility in the cell, and mobile proteasomes can efficiently access substrates throughout the cell, allowing them to effectively regulate cell-compartment-specific activities.
      Title: Proteasome nuclear import mediated by Arc3 can influence efficient DNA damage repair and mitosis in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables actin filament binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Arp2/3 complex-mediated actin nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actin cortical patch assembly IC
    Inferred by Curator
    more info
    		  
    involved_in actin cortical patch organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin filament branching EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Arp2/3 protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT is_active_in actin filament bundle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT is_active_in actomyosin contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell division site HDA PubMed 
    is_active_in cell tip HDA PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    ARP2/3 actin-organizing complex subunit Arc21

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3111115..3112237 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022213.3 → NP_596291.1  ARP2/3 actin-organizing complex subunit Arc21 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596291.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9Y7J4
      Conserved Domains (1) summary
      pfam04062
      Location:1 → 174
      P21-Arc; ARP2/3 complex ARPC3 (21 kDa) subunit
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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