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    PXR1 telomerase inhibitor [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853197, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PXR1
    Official Full Name
    telomerase inhibitor
    Primary source
    SGD:S000003512
    Locus tag
    YGR280C
    See related
    AllianceGenome:SGD:S000003512; FungiDB:YGR280C; VEuPathDB:YGR280C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GNO1
    Summary
    Enables enzyme activator activity and telomerase inhibitor activity. Involved in box C/D sno(s)RNA 3'-end processing and negative regulation of telomere maintenance via telomerase. Located in nucleolus and nucleoplasm. Used to study cancer. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human PINX1 (PIN2 (TERF1) interacting telomerase inhibitor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PXR1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (1050910..1051725, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene U2-type spliceosomal complex subunit CWC22 Neighboring gene putative family 17 glucosidase Neighboring gene ATP-binding cassette transporter YOR1 Neighboring gene glucan 1,3-beta-glucosidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast homolog of human PinX1 is involved in rRNA and small nucleolar RNA maturation, not in telomere elongation inhibition. Guglielmi B, et al. J Biol Chem, 2002 Sep 20. PMID 12107183
    2. Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA. Lin J, et al. Genes Dev, 2004 Feb 15. PMID 14977919, Free PMC Article
    3. The G-patch activators Pfa1 and PINX1 exhibit different modes of interaction with the Prp43 RNA helicase. Mouffok S, et al. RNA Biol, 2021 Apr. PMID 32882145, Free PMC Article
    4. Limited portability of G-patch domains in regulators of the Prp43 RNA helicase required for pre-mRNA splicing and ribosomal RNA maturation in Saccharomyces cerevisiae. Banerjee D, et al. Genetics, 2015 May. PMID 25808954, Free PMC Article
    5. The ATPase and helicase activities of Prp43p are stimulated by the G-patch protein Pfa1p during yeast ribosome biogenesis. Lebaron S, et al. EMBO J, 2009 Dec 16. PMID 19927118, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The G-patch activators Pfa1 and PINX1 exhibit different modes of interaction with the Prp43 RNA helicase.
      Title: The G-patch activators Pfa1 and PINX1 exhibit different modes of interaction with the Prp43 RNA helicase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables enzyme activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables telomerase inhibitor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables telomerase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in box C/D sno(s)RNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of telomere maintenance via telomerase IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of telomere maintenance via telomerase IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    telomerase inhibitor
    NP_011796.1
    • Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      1050910..1051725 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181409.1 → NP_011796.1  TPA: telomerase inhibitor [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011796.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV57, P53335, Q8TG89
      UniProtKB/TrEMBL
      B3LHW5, C7GNF5, C8Z9H3, G2WF03, N1P2R8
      Conserved Domains (1) summary
      pfam01585
      Location:25 → 70
      G-patch; G-patch domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53335.1

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