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    cmk2 MAPK-activated protein kinase Cmk2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541982, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cmk2
    Official Full Name
    MAPK-activated protein kinase Cmk2
    Primary source
    PomBase:SPAC23A1.06c
    Locus tag
    SPOM_SPAC23A1.06C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    mkp2
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    Genomic context

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    See cmk2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003424.3 (4089794..4092099, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene serine palmitoyl transferase A subunit Neighboring gene ncRNA Neighboring gene ubiquitin-protein ligase E3 Neighboring gene 60S ribosomal protein L34

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mkp1 and Mkp2, two MAPKAP-kinase homologues in Schizosaccharomyces pombe, interact with the MAP kinase Sty1. Asp E, et al. Mol Genet Genomics, 2003 Feb. PMID 12589433
    2. The serine/threonine kinase Cmk2 is required for oxidative stress response in fission yeast. Sánchez-Piris M, et al. J Biol Chem, 2002 May 17. PMID 11886858
    3. Cmk2 kinase is essential for survival in arsenite by modulating translation together with RACK1 orthologue Cpc2 in Schizosaccharomyces pombe. Sanchez-Marinas M, et al. Free Radic Biol Med, 2018 Dec. PMID 30236788
    4. Cmk2, a novel serine/threonine kinase in fission yeast. Alemany V, et al. FEBS Lett, 2002 Jul 31. PMID 12135745
    5. Hyperosmosis enhances radiation and hydroxyurea resistance of Schizosaccharomyces pombe checkpoint mutants through the spindle checkpoint and delayed cytokinesis. Alao JP, et al. Mol Microbiol, 2010 Jul 1. PMID 20444100

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cmk2 kinase is essential for survival in arsenite by modulating translation together with RACK1 orthologue Cpc2 in Schizosaccharomyces pombe.
      Title: Cmk2 kinase is essential for survival in arsenite by modulating translation together with RACK1 orthologue Cpc2 in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT is_active_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in ascus epiplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell cortex of cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in division septum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in prospore membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MAPK-activated protein kinase Cmk2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4089794..4092099 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019865.3 → NP_594436.1  MAPK-activated protein kinase Cmk2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594436.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O42844
      Conserved Domains (2) summary
      smart00220
      Location:65 → 351
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:63 → 351
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials