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    tcb1 tricalbin, C2 domain protein (phospholipid binding) ER-plasma membrane tethering protein Tcb1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539288, updated on 14-Nov-2024

    Summary

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    Official Symbol
    tcb1
    Official Full Name
    tricalbin, C2 domain protein (phospholipid binding) ER-plasma membrane tethering protein Tcb1
    Primary source
    PomBase:SPCC962.01
    Locus tag
    SPOM_SPCC962.01
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPCP31B10.09
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    Genomic context

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    See tcb1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003421.2 (541072..546012)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene translation elongation factor 2 eft202 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 60S ribosomal protein eL33 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene survivin Bir1 Neighboring gene ncRNA Neighboring gene importin alpha family nuclear import signal receptor adaptor Cut15

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fission yeast Duc1 links to ER-PM contact sites and influences PM lipid composition and cytokinetic ring anchoring. Willet AH, et al. J Cell Sci, 2024 Sep 15. PMID 39239853, Free PMC Article
    2. Chromatin remodeller Fun30(Fft3) induces nucleosome disassembly to facilitate RNA polymerase II elongation. Lee J, et al. Nat Commun, 2017 Feb 20. PMID 28218250, Free PMC Article
    3. Transcription and RNA-processing in fission yeast mitochondria. Schäfer B, et al. RNA, 2005 May. PMID 15811919, Free PMC Article
    4. The genome sequence of Schizosaccharomyces pombe. Wood V, et al. Nature, 2002 Feb 21. PMID 11859360
    5. The mitochondrial genome of the fission yeast Schizosaccharomyces pombe: highly homologous introns are inserted at the same position of the otherwise less conserved cox1 genes in Schizosaccharomyces pombe and Aspergillus nidulans. Lang BF. EMBO J, 1984 Sep. PMID 6092057, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables protein-membrane adaptor activity IC
    Inferred by Curator
    more info
    		  
    Process Evidence Code Pubs
    involved_in ER to Golgi ceramide transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum-plasma membrane tethering ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    NOT is_active_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cortical endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum-plasma membrane contact site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tricalbin, C2 domain protein (phospholipid binding) ER-plasma membrane tethering protein Tcb1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      541072..546012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022858.3 → NP_587865.1  tricalbin, C2 domain protein (phospholipid binding) ER-plasma membrane tethering protein Tcb1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_587865.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14065, P78884, Q9USG5
      Conserved Domains (3) summary
      cd04045
      Location:757 → 879
      C2C_Tricalbin-like; C2 domain third repeat present in Tricalbin-like proteins
      COG5038
      Location:45 → 1275
      COG5038; Ca2+-dependent lipid-binding protein, contains C2 domain [General function prediction only]
      cl14603
      Location:1086 → 1194
      C2; C2 domain
    Nucleotide Protein
    Heading Accession and Version

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