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    isa2 Fe-sulfur protein Isa2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540984, updated on 18-Sep-2024

    Summary

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    Official Symbol
    isa2
    Official Full Name
    Fe-sulfur protein Isa2
    Primary source
    PomBase:SPBC3B9.17
    Locus tag
    SPOM_SPBC3B9.17
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See isa2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (4020272..4021107)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene nucleoporin, WD repeat Nup120 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene V-type ATPase V1 subunit F

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Formation of [4Fe-4S] clusters in the mitochondrial iron-sulfur cluster assembly machinery. Brancaccio D, et al. J Am Chem Soc, 2014 Nov 19. PMID 25347204
    2. Monothiol glutaredoxin Grx5 interacts with Fe-S scaffold proteins Isa1 and Isa2 and supports Fe-S assembly and DNA integrity in mitochondria of fission yeast. Kim KD, et al. Biochem Biophys Res Commun, 2010 Feb 12. PMID 20085751
    3. Biogenesis of Iron-Sulfur Clusters and Their Role in DNA Metabolism. Shi R, et al. Front Cell Dev Biol, 2021. PMID 34660592, Free PMC Article
    4. Identification of novel coenzyme Q(10) biosynthetic proteins Coq11 and Coq12 in Schizosaccharomyces pombe. Nishida I, et al. J Biol Chem, 2023 Jun. PMID 37156397, Free PMC Article
    5. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Matsuyama A, et al. Nat Biotechnol, 2006 Jul. PMID 16823372

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate that Grx5 plays a central role in Fe-S assembly process through interaction with A-type Fe-S scaffold proteins Isa1 and Isa2.
      Title: Monothiol glutaredoxin Grx5 interacts with Fe-S scaffold proteins Isa1 and Isa2 and supports Fe-S assembly and DNA integrity in mitochondria of fission yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in [4Fe-4S] cluster assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein maturation by [4Fe-4S] cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial [4Fe-4S] assembly complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Fe-sulfur protein Isa2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      4020272..4021107
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022597.3 → NP_596675.1  Fe-sulfur protein Isa2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596675.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O43045
      Conserved Domains (1) summary
      TIGR00049
      Location:99 → 204
      TIGR00049; Iron-sulfur cluster assembly accessory protein
    Nucleotide Protein
    Heading Accession and Version

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