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    spp2 DNA primase large subunit Spp2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539933, updated on 14-Nov-2024

    Summary

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    Official Symbol
    spp2
    Official Full Name
    DNA primase large subunit Spp2
    Primary source
    PomBase:SPBC17D11.06
    Locus tag
    SPOM_SPBC17D11.06
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    pri2
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    Genomic context

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    See spp2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003423.3 (3317773..3319629)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene translation initiation factor eIF3a Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene proteasome regulatory subunit Rpn2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Replication proteins influence the maintenance of telomere length and telomerase protein stability. Dahlén M, et al. Mol Cell Biol, 2003 May. PMID 12697806, Free PMC Article
    2. The B-subunit of DNA polymerase alpha-primase associates with the origin recognition complex for initiation of DNA replication. Uchiyama M, et al. Mol Cell Biol, 2004 Sep. PMID 15314153, Free PMC Article
    3. Primer utilization by DNA polymerase alpha-primase is influenced by its interaction with Mcm10p. Fien K, et al. J Biol Chem, 2004 Apr 16. PMID 14766746
    4. Analysis of fission yeast primase defines the checkpoint responses to aberrant S phase initiation. Tan S, et al. Mol Cell Biol, 2000 Nov. PMID 11027257, Free PMC Article
    5. A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human. Vo TV, et al. Cell, 2016 Jan 14. PMID 26771498, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA primase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication, synthesis of primer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA replication initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of alpha DNA polymerase:primase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of alpha DNA polymerase:primase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    DNA primase large subunit Spp2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3317773..3319629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022301.3 → NP_596380.1  DNA primase large subunit Spp2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596380.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74761, Q9US83
      Conserved Domains (2) summary
      cd07322
      Location:32 → 456
      PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL
      COG2219
      Location:26 → 396
      PRI2; Eukaryotic-type DNA primase, large subunit [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version

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