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    lsm7 U6 snRNP-associated protein Lsm7 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538964, updated on 18-Sep-2024

    Summary

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    Official Symbol
    lsm7
    Official Full Name
    U6 snRNP-associated protein Lsm7
    Primary source
    PomBase:SPCC285.12
    Locus tag
    SPOM_SPCC285.12
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See lsm7 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003421.2 (1818366..1818924)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene SPRY domain membrane protein, specificity factor required for ubiquitination Ear1 Neighboring gene ncRNA Neighboring gene UBA/UAS domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene nucleoporin Nup60 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the LSm657 complex: an assembly intermediate of the LSm1-7 and LSm2-8 rings. Mund M, et al. J Mol Biol, 2011 Nov 25. PMID 22001694
    2. Crystal structures of Lsm3, Lsm4 and Lsm5/6/7 from Schizosaccharomyces pombe. Wu D, et al. PLoS One, 2012. PMID 22615807, Free PMC Article
    3. Molecular basis for the distinct cellular functions of the Lsm1-7 and Lsm2-8 complexes. Montemayor EJ, et al. RNA, 2020 Oct. PMID 32518066, Free PMC Article
    4. LARP7 family proteins have conserved function in telomerase assembly. Collopy LC, et al. Nat Commun, 2018 Feb 8. PMID 29422501, Free PMC Article
    5. The methyl phosphate capping enzyme Bmc1/Bin3 is a stable component of the fission yeast telomerase holoenzyme. Porat J, et al. Nat Commun, 2022 Mar 11. PMID 35277511, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    contributes_to RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U2 snRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables poly(U) RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA cis splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telomerase holoenzyme complex assembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Lsm1-7-Pat1 complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of Lsm1-7-Pat1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Lsm2-8 complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of U2 snRNP EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U5 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U6 snRNP EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of U6 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    part_of spliceosomal tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of telomerase holoenzyme complex EXP
    Inferred from Experiment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    U6 snRNP-associated protein Lsm7

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1818366..1818924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023331.3 → NP_588340.1  U6 snRNP-associated protein Lsm7 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588340.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74499
      Conserved Domains (1) summary
      cd01729
      Location:22 → 109
      LSm7; Like-Sm protein 7
    Nucleotide Protein
    Heading Accession and Version

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