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    TNA1 Tna1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853175, updated on 27-Dec-2024

    Summary

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    Official Symbol
    TNA1
    Official Full Name
    Tna1p
    Primary source
    SGD:S000003492
    Locus tag
    YGR260W
    See related
    AllianceGenome:SGD:S000003492; FungiDB:YGR260W; VEuPathDB:YGR260W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables carboxylic acid transmembrane transporter activity. Involved in quinolinic acid transmembrane transport. Located in cortical endoplasmic reticulum and plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25; gout; porokeratosis; and sialuria. Orthologous to several human genes including SLC17A1 (solute carrier family 17 member 1); SLC17A2 (solute carrier family 17 member 2); and SLC17A3 (solute carrier family 17 member 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TNA1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (1012485..1014089)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Mtm1p Neighboring gene ssDNA endodeoxyribonuclease RAD2 Neighboring gene Apl6p Neighboring gene serine/threonine protein kinase BUD32

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcription of the yeast TNA1 gene is not only regulated by nicotinate but also by p-aminobenzoate. Klebl F, et al. FEBS Lett, 2000 Sep 8. PMID 10984621
    2. Secretion of quinolinic acid, an intermediate in the kynurenine pathway, for utilization in NAD+ biosynthesis in the yeast Saccharomyces cerevisiae. Ohashi K, et al. Eukaryot Cell, 2013 May. PMID 23457190, Free PMC Article
    3. Unified inventory of established and putative transporters encoded within the complete genome of Saccharomyces cerevisiae. Paulsen IT, et al. FEBS Lett, 1998 Jun 23. PMID 9678606
    4. Nrt1 and Tna1-independent export of NAD+ precursor vitamins promotes NAD+ homeostasis and allows engineering of vitamin production. Belenky P, et al. PLoS One, 2011 May 11. PMID 21589930, Free PMC Article
    5. Transcriptional regulation of the Saccharomyces cerevisiae DAL5 gene family and identification of the high affinity nicotinic acid permease TNA1 (YGR260w). Llorente B, et al. FEBS Lett, 2000 Jun 23. PMID 10869563

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables carboxylic acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carboxylic acid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in quinolinic acid transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in cortical endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tna1p
    NP_011776.1
    • High affinity nicotinic acid plasma membrane permease; responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      1012485..1014089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181389.1 → NP_011776.1  TPA: Tna1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011776.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV39, P53322
      UniProtKB/TrEMBL
      B3LHY2, B5VJK2, N1P2P5
      Conserved Domains (1) summary
      cd17327
      Location:87 → 490
      MFS_FEN2_like; Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53322.1

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