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    nak1 PAK-like kinase Nak1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539963, updated on 18-Sep-2024

    Summary

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    Official Symbol
    nak1
    Official Full Name
    PAK-like kinase Nak1
    Primary source
    PomBase:SPBC17F3.02
    Locus tag
    SPOM_SPBC17F3.02
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    mor4; orb3
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    Genomic context

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    See nak1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (2482067..2484425, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene target of rapamycin complex 2 subunit ste20 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ste20/GCK kinase Nak1/Orb3 polarizes the actin cytoskeleton in fission yeast during the cell cycle. Leonhard K, et al. J Cell Sci, 2005 Mar 1. PMID 15731009
    2. Nak1, an essential germinal center (GC) kinase regulates cell morphology and growth in Schizosaccharomyces pombe. Huang TY, et al. J Biol Chem, 2003 Jan 10. PMID 12427731
    3. Cross talk between NDR kinase pathways coordinates cytokinesis with cell separation in Schizosaccharomyces pombe. Gupta S, et al. Eukaryot Cell, 2014 Aug. PMID 24972934, Free PMC Article
    4. Conserved Orb6 phosphorylation sites are essential for polarized cell growth in Schizosaccharomyces pombe. Liu G, et al. PLoS One, 2012. PMID 22629372, Free PMC Article
    5. Nak1 interacts with Hob1 and Wsp1 to regulate cell growth and polarity in Schizosaccharomyces pombe. Huang TY, et al. J Cell Sci, 2005 Jan 1. PMID 15615784

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. our results suggest a model whereby autophosphorylation of Ser291 and phosphorylation of Thr456 by an upstream kinase promote Nak1/Orb6 complex formation and Orb6 activation.
      Title: Conserved Orb6 phosphorylation sites are essential for polarized cell growth in Schizosaccharomyces pombe.
    2. Phosphorylation of the Myo1 TEDS site by Pak1 and Nak1 plays a crucial role in regulating Myo1 localisation and cellular function.
      Title: Ste20-kinase-dependent TEDS-site phosphorylation modulates the dynamic localisation and endocytic function of the fission yeast class I myosin, Myo1.
    3. Nak1/Orb3 polarizes the actin cytoskeleton in fission yeast during the cell cycle
      Title: Ste20/GCK kinase Nak1/Orb3 polarizes the actin cytoskeleton in fission yeast during the cell cycle.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RAM/MOR signaling NAS
    Non-traceable Author Statement
    more info
    		  
    involved_in establishment or maintenance of actin cytoskeleton polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to medial cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of establishment or maintenance of bipolar cell polarity regulating cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in mitotic actomyosin contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in new mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PAK-like kinase Nak1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2482067..2484425 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021931.3 → NP_596023.1  PAK-like kinase Nak1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596023.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O75011
      Conserved Domains (2) summary
      smart00220
      Location:10 → 264
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8 → 282
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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