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    Arhgef4 Rho guanine nucleotide exchange factor 4 [ Mus musculus (house mouse) ]

    Gene ID: 226970, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arhgef4provided by MGI
    Official Full Name
    Rho guanine nucleotide exchange factor 4provided by MGI
    Primary source
    MGI:MGI:2442507
    See related
    Ensembl:ENSMUSG00000037509 AllianceGenome:MGI:2442507
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Asef; 9330140K16Rik; C230030N03Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and protein domain specific binding activity. Predicted to be involved in filopodium assembly and lamellipodium assembly. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in spinal cord and ventricular layer. Orthologous to human ARHGEF4 (Rho guanine nucleotide exchange factor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 57.8), frontal lobe adult (RPKM 45.1) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arhgef4 in Genome Data Viewer
    Location:
    1 B; 1 13.34 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (34717263..34851819)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (34677949..34812754)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene PHD finger protein 19 pseudogene Neighboring gene predicted gene, 38647 Neighboring gene predicted gene, 32920 Neighboring gene alpha-endosulfine pseudogene Neighboring gene STARR-seq mESC enhancer starr_00584 Neighboring gene predicted gene, 32790 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:34859246-34859433 Neighboring gene small integral membrane protein 39 Neighboring gene family with sequence similarity 168, member B Neighboring gene STARR-seq mESC enhancer starr_00587 Neighboring gene pleckstrin homology domain containing, family B (evectins) member 2 Neighboring gene STARR-positive B cell enhancer mm9_chr1:34924123-34924424

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rho Guanine Nucleotide Exchange Factor 4 (Arhgef4) Deficiency Enhances Spatial and Object Recognition Memory. Yoo KS, et al. Exp Neurobiol, 2020 Oct 31. PMID 33154196, Free PMC Article
    2. Asef controls vascular endothelial permeability and barrier recovery in the lung. Tian X, et al. Mol Biol Cell, 2015 Feb 15. PMID 25518936, Free PMC Article
    3. The adenomatous polyposis coli-associated guanine nucleotide exchange factor Asef is involved in angiogenesis. Kawasaki Y, et al. J Biol Chem, 2010 Jan 8. PMID 19897489, Free PMC Article
    4. Asef mediates HGF protective effects against LPS-induced lung injury and endothelial barrier dysfunction. Meng F, et al. Am J Physiol Lung Cell Mol Physiol, 2015 Mar 1. PMID 25539852, Free PMC Article
    5. The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice. Kawasaki Y, et al. EMBO Rep, 2009 Dec. PMID 19893577, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Asef has a role in HGF-mediated protection against endothelial hyperpermeability and lung injury.
      Title: Asef controls vascular endothelial permeability and barrier recovery in the lung.
    2. these results demonstrate potent anti-inflammatory effects by HGF and delineate a key role of Asef in the mediation of the HGF barrier protective and anti-inflammatory effects.
      Title: Asef mediates HGF protective effects against LPS-induced lung injury and endothelial barrier dysfunction.
    3. Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice.
      Title: The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in filopodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lamellipodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 4
    Names
    APC-stimulated guanine nucleotide exchange factor
    Rho guanine nucleotide exchange factor (GEF) 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368773.1 → NP_001355702.1  rho guanine nucleotide exchange factor 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC107738, AC107766, AC157813
      Consensus CDS
      CCDS87817.1
      UniProtKB/TrEMBL
      E9PYK8
      Related
      ENSMUSP00000124213.3, ENSMUST00000159747.9
      Conserved Domains (3) summary
      cd11973
      Location:1344 → 1416
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      cd00160
      Location:1450 → 1631
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01224
      Location:1637 → 1776
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

    2. NM_183019.3 → NP_898840.2  rho guanine nucleotide exchange factor 4 isoform 2

      See identical proteins and their annotated locations for NP_898840.2

      Status: VALIDATED

      Source sequence(s)
      AC107738
      Consensus CDS
      CCDS14872.1
      UniProtKB/Swiss-Prot
      Q7TNR9, Q80TJ6
      UniProtKB/TrEMBL
      Q3TDW8, Q3TQN9, Q3UYJ6
      Related
      ENSMUSP00000035980.10, ENSMUST00000047664.16
      Conserved Domains (3) summary
      cd00160
      Location:79 → 260
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01224
      Location:266 → 405
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      cl17036
      Location:1 → 45
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      34717263..34851819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TNR9.2 GenPept UniProtKB/Swiss-Prot:Q7TNR9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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