Cer1 cerberus 1, DAN family BMP antagonist [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cer1provided by MGI
Official Full Name: cerberus 1, DAN family BMP antagonistprovided by MGI
Primary source: MGI:MGI:1201414
See related: Ensembl:ENSMUSG00000038192 AllianceGenome:MGI:1201414
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cerl; Cerl1; Cerr1; cer-1
Summary: Enables protein homodimerization activity. Involved in several processes, including growth plate cartilage chondrocyte proliferation; negative regulation of mesoderm development; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within several processes, including cellular response to cadmium ion; negative regulation of BMP signaling pathway; and signal transduction involved in regulation of gene expression. Located in extracellular space. Is expressed in several structures, including alimentary system; blastocyst; brain; genitourinary system; and paraxial mesenchyme. Orthologous to human CER1 (cerberus 1, DAN family BMP antagonist). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 4 C3; 4 39.4 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (82799988..82803388, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (82881751..82885151, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hhex and Cer1 are indispensable components of the Sox17 pathway for cardiopoiesis.
Title: Hhex and Cer1 mediate the Sox17 pathway for cardiac mesoderm formation in embryonic stem cells.
regulates the Nodal/Bone Morphogenetic Protein antagonist Cerberus and the Baf60c/Smarcd3 subunit of the Brg1/Brm-associated factors (BAF) chromatin-remodelling complex
Title: The G-protein-coupled receptor APJ is expressed in the second heart field and regulates Cerberus-Baf60c axis in embryonic stem cell cardiomyogenesis.
a good marker for quantification of definitive endoderm differentiation of mouse and human ES/iPS cells
Title: Secreted cerberus1 as a marker for quantification of definitive endoderm differentiation of the pluripotent stem cells.
successful identification of an association with CER1 in humans together with our mouse study suggests that CER1 may play a role in the development of bone or its metabolism
Title: Genome-wide haplotype association mapping in mice identifies a genetic variant in CER1 associated with BMD and fracture in southern Chinese women.
Some early Cer1-expressing cells do contribute to the AVE when it becomes established at E5.5.
Title: The anterior visceral endoderm of the mouse embryo is established from both preimplantation precursor cells and by de novo gene expression after implantation.
Cerberus-like and Lefty-1 function redundantly to modulate Nodal signaling during gastrulation and regulate patterning of the primitive streak
Title: Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks.
Role of Cerberus-like in mouse embryogenesis
Title: Goosecoid and cerberus-like do not interact during mouse embryogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cer1 (e-PCR), detects polymorphism
- UniSTS:141323

NoName (e-PCR)
- UniSTS:491299

Cer1 (e-PCR), detects polymorphism
- UniSTS:495950

AF012244 (e-PCR)
- UniSTS:179023

Cer1 (e-PCR), detects polymorphism
- UniSTS:506794

Cer1 (e-PCR), detects polymorphism
- UniSTS:532666

NoName (e-PCR)
- UniSTS:234947

Cer1 (e-PCR), detects polymorphism
- UniSTS:158684

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables BMP binding	IEA Inferred from Electronic Annotation more info
enables BMP binding	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables morphogen activity	IBA Inferred from Biological aspect of Ancestor more info
enables morphogen activity	IEA Inferred from Electronic Annotation more info
enables morphogen activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior axis specification	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within anterior/posterior axis specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within anterior/posterior pattern specification	IDA Inferred from Direct Assay more info	PubMed
involved_in bone mineralization	IEA Inferred from Electronic Annotation more info
involved_in bone mineralization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell migration involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cellular response to cadmium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in determination of dorsal identity	IEA Inferred from Electronic Annotation more info
involved_in determination of dorsal identity	ISO Inferred from Sequence Orthology more info
involved_in determination of heart left/right asymmetry	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in growth plate cartilage chondrocyte proliferation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in negative regulation of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of activin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of mesoderm development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mesoderm development	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
involved_in sequestering of BMP in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in sequestering of BMP in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
involved_in sequestering of BMP in extracellular matrix	ISO Inferred from Sequence Orthology more info
involved_in signal transduction involved in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction involved in regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in ureteric bud development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cerberus

Names: cer-l; cerberus 1 homolog; cerberus homolog; cerberus-like protein; cerberus-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.