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    Ilvbl ilvB (bacterial acetolactate synthase)-like [ Mus musculus (house mouse) ]

    Gene ID: 216136, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Ilvblprovided by MGI
    Official Full Name
    ilvB (bacterial acetolactate synthase)-likeprovided by MGI
    Primary source
    MGI:MGI:1351911
    See related
    Ensembl:ENSMUSG00000032763 AllianceGenome:MGI:1351911
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5830463I21
    Summary
    Predicted to enable acetolactate synthase activity and flavin adenine dinucleotide binding activity. Predicted to be involved in L-valine biosynthetic process; fatty acid alpha-oxidation; and isoleucine biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of acetolactate synthase complex. Orthologous to human ILVBL (ilvB acetolactate synthase like). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in thymus adult (RPKM 37.8), duodenum adult (RPKM 32.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ilvbl in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (78410178..78420336)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (78574344..78584502)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase 4a1 pseudogene Neighboring gene vomeronasal 2, receptor, pseudogene 92 Neighboring gene STARR-positive B cell enhancer ABC_E8865 Neighboring gene STARR-positive B cell enhancer ABC_E2945 Neighboring gene synapse defective 1, Rho GTPase, homolog 1 (C. elegans) Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:78057364-78057547 Neighboring gene predicted gene, 30346

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Role of 2-hydroxy acyl-CoA lyase HACL2 in odd-chain fatty acid production via α-oxidation in vivo. Mori K, et al. Mol Biol Cell, 2023 Aug 1. PMID 37285239, Free PMC Article
    2. Members of Bitter Taste Receptor Cluster Tas2r143/Tas2r135/Tas2r126 Are Expressed in the Epithelium of Murine Airways and Other Non-gustatory Tissues. Liu S, et al. Front Physiol, 2017. PMID 29163195, Free PMC Article
    3. The reactive pyruvate metabolite dimethylglyoxal mediates neurological consequences of diabetes. Rhein S, et al. Nat Commun, 2024 Jul 10. PMID 38987239, Free PMC Article
    4. CHIP as a membrane-shuttling proteostasis sensor. Kopp Y, et al. Elife, 2017 Nov 1. PMID 29091030, Free PMC Article
    5. TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis. Yang Y, et al. EMBO J, 2022 Jul 18. PMID 35670107, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetolactate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine pyrophosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-valine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid alpha-oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid alpha-oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in isoleucine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of acetolactate synthase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    2-hydroxyacyl-CoA lyase 2
    Names
    acetolactate synthase-like protein
    ilvB-like protein
    NP_001346230.1
    NP_001346231.1
    NP_001346232.1
    NP_776112.1
    XP_011241702.1
    XP_030100875.1
    XP_030100876.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359301.1 → NP_001346230.1  2-hydroxyacyl-CoA lyase 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC153887, AI842669, BC056459, BY231452
      UniProtKB/TrEMBL
      A0A1W2P8E1
      Conserved Domains (1) summary
      cl28198
      Location:63 → 596
      IlvB; Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme [Amino acid transport and metabolism, Coenzyme transport and metabolism]

    2. NM_001359302.1 → NP_001346231.1  2-hydroxyacyl-CoA lyase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI842669, AK133553, AK146075
      Consensus CDS
      CCDS23966.1
      UniProtKB/Swiss-Prot
      Q3UNZ4, Q3UZY5, Q8BU33
      UniProtKB/TrEMBL
      A0A1W2P8E1
      Related
      ENSMUSP00000151263.2, ENSMUST00000218885.2
      Conserved Domains (1) summary
      PRK05858
      Location:53 → 586
      PRK05858; acetolactate synthase

    3. NM_001359303.1 → NP_001346232.1  2-hydroxyacyl-CoA lyase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK133553, AK143918
      Consensus CDS
      CCDS88046.1
      Related
      ENSMUSP00000151480.2, ENSMUST00000218271.2
      Conserved Domains (1) summary
      PRK05858
      Location:53 → 361
      PRK05858; acetolactate synthase

    4. NM_173751.4 → NP_776112.1  2-hydroxyacyl-CoA lyase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BC056459, CD768274, CK789563
      Consensus CDS
      CCDS23966.1
      UniProtKB/Swiss-Prot
      Q3UNZ4, Q3UZY5, Q8BU33
      UniProtKB/TrEMBL
      A0A1W2P8E1
      Related
      ENSMUSP00000101023.4, ENSMUST00000105384.5
      Conserved Domains (1) summary
      PRK05858
      Location:53 → 586
      PRK05858; acetolactate synthase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      78410178..78420336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243400.3 → XP_011241702.1  2-hydroxyacyl-CoA lyase 2 isoform X2

      UniProtKB/Swiss-Prot
      Q3UNZ4, Q3UZY5, Q8BU33
      UniProtKB/TrEMBL
      A0A1W2P8E1
      Conserved Domains (1) summary
      PRK05858
      Location:53 → 586
      PRK05858; acetolactate synthase

    2. XM_030245015.2 → XP_030100875.1  2-hydroxyacyl-CoA lyase 2 isoform X1

      UniProtKB/TrEMBL
      A0A1W2P8E1
      Conserved Domains (1) summary
      PRK05858
      Location:65 → 598
      PRK05858; acetolactate synthase

    3. XM_030245016.2 → XP_030100876.1  2-hydroxyacyl-CoA lyase 2 isoform X3

      Conserved Domains (1) summary
      PRK05858
      Location:65 → 373
      PRK05858; acetolactate synthase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BU33.1 GenPept UniProtKB/Swiss-Prot:Q8BU33

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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