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    Sgcg sarcoglycan, gamma (dystrophin-associated glycoprotein) [ Mus musculus (house mouse) ]

    Gene ID: 24053, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sgcgprovided by MGI
    Official Full Name
    sarcoglycan, gamma (dystrophin-associated glycoprotein)provided by MGI
    Primary source
    MGI:MGI:1346524
    See related
    Ensembl:ENSMUSG00000035296 AllianceGenome:MGI:1346524
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    35kDa; gamma-SG; 5430420E18Rik
    Summary
    Acts upstream of or within gene expression. Located in sarcolemma. Part of sarcoglycan complex. Is expressed in tongue; urinary system; and vertebral axis musculature. Used to study autosomal recessive limb-girdle muscular dystrophy type 2C and limb-girdle muscular dystrophy. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2C and type 2 diabetes mellitus. Orthologous to human SGCG (sarcoglycan gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in heart adult (RPKM 37.1), mammary gland adult (RPKM 4.1) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Sgcg in Genome Data Viewer
    Location:
    14 D1; 14 32.27 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (61456555..61495939, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (61219106..61275062, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor receptor superfamily, member 19 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:61665054-61665237 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:61675420-61675649 Neighboring gene predicted gene, 41167 Neighboring gene predicted gene, 41168 Neighboring gene STARR-positive B cell enhancer ABC_E8562 Neighboring gene sacsin Neighboring gene predicted gene, 17778 Neighboring gene eukaryotic translation initiation factor 3, subunit E pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cardiac muscle tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within membrane organization TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    part_of dystroglycan complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of sarcoglycan complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of sarcoglycan complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    gamma-sarcoglycan
    Names
    35 kDa dystrophin-associated glycoprotein
    35DAG
    sarcoglycan, gamma (35kD dystrophin-associated glycoprotein)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011892.3NP_036022.1  gamma-sarcoglycan

      See identical proteins and their annotated locations for NP_036022.1

      Status: VALIDATED

      Source sequence(s)
      AC138718, AK132610
      Consensus CDS
      CCDS27181.1
      UniProtKB/Swiss-Prot
      P82348
      UniProtKB/TrEMBL
      Q9EQ83
      Related
      ENSMUSP00000077106.6, ENSMUST00000077954.13
      Conserved Domains (1) summary
      pfam04790
      Location:25278
      Sarcoglycan_1; Sarcoglycan complex subunit protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      61456555..61495939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158597.1XP_036014490.1  gamma-sarcoglycan isoform X1

      UniProtKB/Swiss-Prot
      P82348
      UniProtKB/TrEMBL
      Q9EQ83
      Related
      ENSMUSP00000112576.2, ENSMUST00000121148.8
      Conserved Domains (1) summary
      pfam04790
      Location:25278
      Sarcoglycan_1; Sarcoglycan complex subunit protein