Lyzl6 lysozyme-like 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lyzl6provided by MGI
Official Full Name: lysozyme-like 6provided by MGI
Primary source: MGI:MGI:1916694
See related: Ensembl:ENSMUSG00000020945 AllianceGenome:MGI:1916694
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lyc1; Lyzb; 1700023H08Rik
Summary: Predicted to enable lysozyme activity. Predicted to be involved in defense response to bacterium and fusion of sperm to egg plasma membrane involved in single fertilization. Located in sperm midpiece. Orthologous to human LYZL6 (lysozyme like 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 87.6) See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 67.4 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (103521894..103529716, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (103631068..103638890, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lysozyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysozyme activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in fertilization	ISO Inferred from Sequence Orthology more info
involved_in fertilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in fusion of sperm to egg plasma membrane involved in single fertilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in fusion of sperm to egg plasma membrane involved in single fertilization	ISO Inferred from Sequence Orthology more info
involved_in fusion of sperm to egg plasma membrane involved in single fertilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in killing of cells of another organism	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in acrosomal vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in sperm flagellum	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm midpiece	IDA Inferred from Direct Assay more info	PubMed
located_in sperm plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sperm plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: lysozyme-like protein 6

Names: lysozyme b; lysozyme-like protein 1

NP_001343401.1

EC 3.2.1.17

NP_081359.1

EC 3.2.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356472.2 → NP_001343401.1 lysozyme-like protein 6 precursor

Status: VALIDATED

Source sequence(s)

AK006279, AV254473, BY092087

Consensus CDS

CCDS25519.1

UniProtKB/Swiss-Prot

Q9DA11

UniProtKB/TrEMBL

A0A077S2U3

Related

ENSMUSP00000102628.2, ENSMUST00000107014.8

Conserved Domains (1) summary

cd00119
Location:21 → 142

LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...
NM_027083.3 → NP_081359.1 lysozyme-like protein 6 precursor

See identical proteins and their annotated locations for NP_081359.1

Status: VALIDATED

Source sequence(s)

AV254473, BC048617, BY092087

Consensus CDS

CCDS25519.1

UniProtKB/Swiss-Prot

Q9DA11

UniProtKB/TrEMBL

A0A077S2U3

Related

ENSMUSP00000021328.8, ENSMUST00000021328.8

Conserved Domains (1) summary

cd00119
Location:21 → 142

LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...