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    Ptprg protein tyrosine phosphatase receptor type G [ Mus musculus (house mouse) ]

    Gene ID: 19270, updated on 3-Dec-2024

    Summary

    Official Symbol
    Ptprgprovided by MGI
    Official Full Name
    protein tyrosine phosphatase receptor type Gprovided by MGI
    Primary source
    MGI:MGI:97814
    See related
    Ensembl:ENSMUSG00000121513 AllianceGenome:MGI:97814
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RPTPgamma; 5430405N12Rik
    Summary
    Predicted to enable identical protein binding activity and protein tyrosine phosphatase activity. Predicted to be involved in several processes, including negative regulation of epithelial cell migration; negative regulation of neuron projection development; and neuron projection development. Predicted to be located in extracellular space. Is expressed in several structures, including central nervous system and retina. Orthologous to human PTPRG (protein tyrosine phosphatase receptor type G). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 13.7), ovary adult (RPKM 13.0) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Ptprg in Genome Data Viewer
    Location:
    14 A1; 14 6.33 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (10227722..10916341, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (11553440..12242041)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35954 Neighboring gene predicted gene, 24578 Neighboring gene centrosomal protein 15 Neighboring gene STARR-seq mESC enhancer starr_35952 Neighboring gene STARR-seq mESC enhancer starr_35951 Neighboring gene predicted gene, 53822 Neighboring gene STARR-seq mESC enhancer starr_35947 Neighboring gene STARR-seq mESC enhancer starr_35940 Neighboring gene STARR-seq mESC enhancer starr_35939 Neighboring gene STARR-seq mESC enhancer starr_35937 Neighboring gene STARR-seq mESC enhancer starr_35926 Neighboring gene STARR-seq mESC enhancer starr_35924 Neighboring gene predicted gene, 52128 Neighboring gene STARR-seq mESC enhancer starr_35922 Neighboring gene STARR-seq mESC enhancer starr_35921 Neighboring gene STARR-seq mESC enhancer starr_35920 Neighboring gene STARR-seq mESC enhancer starr_35919 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_35918 Neighboring gene STARR-seq mESC enhancer starr_35917 Neighboring gene predicted gene, 25466

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    receptor-type tyrosine-protein phosphatase gamma
    Names
    Protein-tyrosine phosphatase gamma precursor (R-PTP-gamma)
    R-PTP-gamma
    NP_001334522.1
    NP_033007.2
    XP_006518019.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347593.1NP_001334522.1  receptor-type tyrosine-protein phosphatase gamma isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is much shorter than isoform 1.
      Source sequence(s)
      AC154682, AK144283, CF724833
      Consensus CDS
      CCDS84092.1
      UniProtKB/TrEMBL
      Q3UND4
    2. NM_008981.3NP_033007.2  receptor-type tyrosine-protein phosphatase gamma isoform 1 precursor

      See identical proteins and their annotated locations for NP_033007.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC154682, AK134814, BC079595, L09562
      Consensus CDS
      CCDS26816.1
      UniProtKB/Swiss-Prot
      Q05909
      UniProtKB/TrEMBL
      A0A991ELE1, A0AAU6PXG9
      Related
      ENSMUSP00000159543.1, ENSMUST00000248537.1
      Conserved Domains (5) summary
      PLN02179
      Location:17272
      PLN02179; carbonic anhydrase
      smart00194
      Location:8441115
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:8731115
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:348438
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd03122
      Location:67319
      alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      10227722..10916341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517956.5XP_006518019.1  receptor-type tyrosine-protein phosphatase gamma isoform X1

      UniProtKB/TrEMBL
      A0AAU6R5M1, A0AAU6R6B2
      Conserved Domains (5) summary
      PRK12495
      Location:613689
      PRK12495; hypothetical protein; Provisional
      cd00063
      Location:348438
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd03122
      Location:67319
      alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
      cd17667
      Location:8161089
      R-PTPc-G-1; catalytic domain of receptor-type tyrosine-protein phosphatase G, repeat 1
      cd17670
      Location:11731377
      R-PTP-G-2; PTP-like domain of receptor-type tyrosine-protein phosphatase G, repeat 2