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    Fsd1 fibronectin type 3 and SPRY domain-containing protein [ Mus musculus (house mouse) ]

    Gene ID: 240121, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fsd1provided by MGI
    Official Full Name
    fibronectin type 3 and SPRY domain-containing proteinprovided by MGI
    Primary source
    MGI:MGI:1934858
    See related
    Ensembl:ENSMUSG00000011589 AllianceGenome:MGI:1934858
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable identical protein binding activity and microtubule binding activity. Predicted to be involved in cytoplasmic microtubule organization; regulation of cytokinesis; and regulation of mitotic spindle organization. Predicted to be located in centrosome. Predicted to be active in microtubule. Is expressed in nervous system and sensory organ. Orthologous to human FSD1 (fibronectin type III and SPRY domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 45.8), whole brain E14.5 (RPKM 38.0) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Fsd1 in Genome Data Viewer
    Location:
    17 D; 17 29.1 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56293475..56303881)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (55986462..55996883)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 16712 Neighboring gene STARR-positive B cell enhancer ABC_E2496 Neighboring gene YJU2 splicing factor Neighboring gene src homology 2 domain-containing transforming protein D Neighboring gene signal transducing adaptor family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E2497 Neighboring gene MPN domain containing Neighboring gene bolA-like 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC58341

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytoplasmic microtubule organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytoplasmic microtubule organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytokinesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of mitotic spindle organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cleavage furrow IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    fibronectin type III and SPRY domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411202.1NP_001398131.1  fibronectin type III and SPRY domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT009719
    2. NM_001411203.1NP_001398132.1  fibronectin type III and SPRY domain-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT009719
    3. NM_001411204.1NP_001398133.1  fibronectin type III and SPRY domain-containing protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT009719
    4. NM_001411205.1NP_001398134.1  fibronectin type III and SPRY domain-containing protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      CT009719
    5. NM_001411206.1NP_001398135.1  fibronectin type III and SPRY domain-containing protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      CT009719
    6. NM_001411207.1NP_001398136.1  fibronectin type III and SPRY domain-containing protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      CT009719
    7. NM_001411208.1NP_001398137.1  fibronectin type III and SPRY domain-containing protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      CT009719
    8. NM_001411209.1NP_001398138.1  fibronectin type III and SPRY domain-containing protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      CT009719
    9. NM_183178.3NP_899001.1  fibronectin type III and SPRY domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_899001.1

      Status: VALIDATED

      Source sequence(s)
      CT009719
      Consensus CDS
      CCDS37661.1
      UniProtKB/Swiss-Prot
      Q3UNE6, Q7TPM6
      Related
      ENSMUSP00000011733.9, ENSMUST00000011733.9
      Conserved Domains (3) summary
      cd00063
      Location:165265
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12901
      Location:270476
      SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus
      cl23765
      Location:4120
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RNA

    1. NR_177196.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT009719

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      56293475..56303881
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)