U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Arhgap15 Rho GTPase activating protein 15 [ Mus musculus (house mouse) ]

    Gene ID: 76117, updated on 9-Dec-2024

    Summary

    Official Symbol
    Arhgap15provided by MGI
    Official Full Name
    Rho GTPase activating protein 15provided by MGI
    Primary source
    MGI:MGI:1923367
    See related
    Ensembl:ENSMUSG00000049744 AllianceGenome:MGI:1923367
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5830480G12Rik
    Summary
    The protein encoded by this gene is a RAC GTPase-activating protein that is regulated through its PH domain and by recruitment to the membrane. The protein accelerates hydrolysis of guanosine triphosphate to guanosine diphosphate to repress Rac activity. Knock-out of Arhgap15 function demonstrates that this gene is required to regulate multiple functions in macrophages and neutrophils. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
    Expression
    Broad expression in thymus adult (RPKM 1.0), cortex adult (RPKM 0.9) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Arhgap15 in Genome Data Viewer
    Location:
    2 B; 2 26.13 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (43638786..44285965)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (43748798..44395953)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11131 Neighboring gene STARR-positive B cell enhancer mm9_chr2:43441000-43441301 Neighboring gene STARR-positive B cell enhancer mm9_chr2:43478445-43478746 Neighboring gene STARR-seq mESC enhancer starr_04386 Neighboring gene kynureninase Neighboring gene STARR-positive B cell enhancer ABC_E4451 Neighboring gene STARR-seq mESC enhancer starr_04387 Neighboring gene STARR-positive B cell enhancer ABC_E9513 Neighboring gene STARR-seq mESC enhancer starr_04388 Neighboring gene STARR-positive B cell enhancer ABC_E636 Neighboring gene predicted gene, 30374 Neighboring gene predicted gene, 39804 Neighboring gene Rho GTPase activating protein 15, opposite strand Neighboring gene STARR-seq mESC enhancer starr_04390 Neighboring gene STARR-seq mESC enhancer starr_04391 Neighboring gene STARR-seq mESC enhancer starr_04393 Neighboring gene STARR-positive B cell enhancer mm9_chr2:44200426-44200727 Neighboring gene predicted gene, 52508 Neighboring gene STARR-seq mESC enhancer starr_04394 Neighboring gene predicted gene, 39805 Neighboring gene predicted gene, 39806

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rho GTPase-activating protein 15
    Names
    rho-type GTPase-activating protein 15

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301831.1NP_001288760.1  rho GTPase-activating protein 15 isoform 3

      See identical proteins and their annotated locations for NP_001288760.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK036520, AK040796, AL844535
      Consensus CDS
      CCDS79793.1
      UniProtKB/TrEMBL
      A0A2X0SSE2, B1AW40
      Related
      ENSMUSP00000108443.2, ENSMUST00000112824.8
      Conserved Domains (3) summary
      cd13233
      Location:89198
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:88196
      PH; PH domain
      cl02570
      Location:285423
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    2. NM_001301832.1NP_001288761.1  rho GTPase-activating protein 15 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate exon in the 5' end of the transcript compared to variant 1. This causes translation initiation at a downstream AUG and results in an isoform (4) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK036520, AK040796, BF453909
      Conserved Domains (2) summary
      cd04403
      Location:150336
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cl17171
      Location:163
      PH-like; Pleckstrin homology-like domain
    3. NM_001364029.1NP_001350958.1  rho GTPase-activating protein 15 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL732320, AL844535, AL845160, AL928611, AL935152
      UniProtKB/TrEMBL
      A0A2X0SSE2
      Conserved Domains (2) summary
      cd04403
      Location:240426
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:44153
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    4. NM_153820.3NP_722542.2  rho GTPase-activating protein 15 isoform 1

      See identical proteins and their annotated locations for NP_722542.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI840874, AK036520, AK040796, BC034881
      Consensus CDS
      CCDS16019.1
      UniProtKB/Swiss-Prot
      Q3T9M8, Q3TCU0, Q811M1, Q8C0I5, Q8JZY0
      UniProtKB/TrEMBL
      A0A2X0SSE2
      Related
      ENSMUSP00000056461.7, ENSMUST00000055776.8
      Conserved Domains (3) summary
      cd04403
      Location:285471
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:89198
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:88196
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      43638786..44285965
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162663.1XP_036018556.1  rho GTPase-activating protein 15 isoform X3

      UniProtKB/TrEMBL
      A0A2X0SSE2
      Conserved Domains (2) summary
      cd13233
      Location:89198
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      cl02570
      Location:285387
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    2. XM_006498402.5XP_006498465.1  rho GTPase-activating protein 15 isoform X4

      Conserved Domains (2) summary
      cd13233
      Location:89198
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      cl02570
      Location:285404
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    3. XM_006498398.5XP_006498461.1  rho GTPase-activating protein 15 isoform X1

      UniProtKB/TrEMBL
      A0A2X0SSE2
      Conserved Domains (2) summary
      cd04403
      Location:262448
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:66175
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    4. XM_006498399.5XP_006498462.1  rho GTPase-activating protein 15 isoform X2

      See identical proteins and their annotated locations for XP_006498462.1

      UniProtKB/TrEMBL
      A0A2X0SSE2
      Conserved Domains (2) summary
      cd04403
      Location:252438
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:56165
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    5. XM_006498403.3XP_006498466.1  rho GTPase-activating protein 15 isoform X5

      See identical proteins and their annotated locations for XP_006498466.1

      UniProtKB/TrEMBL
      B2X2D4
      Conserved Domains (1) summary
      cd04403
      Location:91247
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001025377.1: Suppressed sequence

      Description
      NM_001025377.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.