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    Rimbp2 RIMS binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 231760, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rimbp2provided by MGI
    Official Full Name
    RIMS binding protein 2provided by MGI
    Primary source
    MGI:MGI:2443235
    See related
    Ensembl:ENSMUSG00000029420 AllianceGenome:MGI:2443235
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0318; A930033C01Rik
    Summary
    Enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. A structural constituent of presynaptic active zone. Involved in regulation of calcium-dependent activation of synaptic vesicle fusion and regulation of presynaptic membrane potential. Is active in calyx of Held; glutamatergic synapse; and presynaptic active zone cytoplasmic component. Orthologous to human RIMBP2 (RIMS binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 19.2), frontal lobe adult (RPKM 17.0) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rimbp2 in Genome Data Viewer
    Location:
    5 G1.3; 5 67.91 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (128834852..129030636, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (128757788..128953644, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14427 Neighboring gene predicted gene, 33995 Neighboring gene piwi-like RNA-mediated gene silencing 1 Neighboring gene predicted gene 42875 Neighboring gene predicted gene, 34057 Neighboring gene syntaxin 2 Neighboring gene RAN, member RAS oncogene family

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in calyx of Held IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in calyx of Held IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynaptic active zone cytoplasmic component IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081388.2NP_001074857.1  RIMS-binding protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001074857.1

      Status: VALIDATED

      Source sequence(s)
      AK038814, AK044685, AK147417, BC151100, BP762839, CF745262, CJ115058
      Consensus CDS
      CCDS39288.1
      UniProtKB/Swiss-Prot
      B9EKT4, E9QPF5, Q80U40
      UniProtKB/TrEMBL
      D3YXR8
      Related
      ENSMUSP00000106978.2, ENSMUST00000111346.6
      Conserved Domains (6) summary
      cd12012
      Location:879940
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:9831043
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:192252
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd00063
      Location:508594
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:414478
      fn3; Fibronectin type III domain
      pfam15152
      Location:644685
      Kisspeptin; Kisspeptin
    2. NM_001310733.1NP_001297662.1  RIMS-binding protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC111089, AK044685, AK147417, BC151100, BP762839, CF745262, CJ115058
      Consensus CDS
      CCDS80415.1
      UniProtKB/Swiss-Prot
      B9EKT4, E9QPF5, Q80U40
      UniProtKB/TrEMBL
      A0A0G2JFB0
      Related
      ENSMUSP00000143099.2, ENSMUST00000200470.5
      Conserved Domains (8) summary
      cd12012
      Location:872933
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:9761036
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:185245
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd00063
      Location:501587
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:407471
      fn3; Fibronectin type III domain
      pfam15152
      Location:637678
      Kisspeptin; Kisspeptin
      cd16269
      Location:5670
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:188
      GBP_C; Guanylate-binding protein, C-terminal domain
    3. NM_001378900.1NP_001365829.1  RIMS-binding protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC110566, AC111089, AC116715
      UniProtKB/Swiss-Prot
      B9EKT4, E9QPF5, Q80U40
      Conserved Domains (8) summary
      cd12012
      Location:872933
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:9761036
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:185245
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      smart00060
      Location:314391
      FN3; Fibronectin type 3 domain
      PHA03321
      Location:586730
      PHA03321; tegument protein VP11/12; Provisional
      cd00063
      Location:501587
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:407474
      fn3; Fibronectin type III domain
      pfam15905
      Location:488
      HMMR_N; Hyaluronan mediated motility receptor N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      128834852..129030636 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320870.3XP_017176359.1  RIMS-binding protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A571BDA2
      Conserved Domains (8) summary
      cd12012
      Location:11161177
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:12201280
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:192252
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      PHA03321
      Location:593737
      PHA03321; tegument protein VP11/12; Provisional
      cd00063
      Location:508594
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      TIGR02168
      Location:287
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00041
      Location:414481
      fn3; Fibronectin type III domain
      pfam15152
      Location:644685
      Kisspeptin
    2. XM_006504296.4XP_006504359.1  RIMS-binding protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A571BDA2
      Conserved Domains (8) summary
      cd12012
      Location:11161177
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:12201280
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:192252
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      PHA03321
      Location:593737
      PHA03321; tegument protein VP11/12; Provisional
      cd00063
      Location:508594
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      TIGR02168
      Location:287
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00041
      Location:414481
      fn3; Fibronectin type III domain
      pfam15152
      Location:644685
      Kisspeptin
    3. XM_006504297.5XP_006504360.1  RIMS-binding protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A571BDA2
      Conserved Domains (9) summary
      cd12012
      Location:11091170
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:12131273
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:185245
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      smart00060
      Location:314391
      FN3; Fibronectin type 3 domain
      PHA03321
      Location:586730
      PHA03321; tegument protein VP11/12; Provisional
      cd00063
      Location:501587
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:407474
      fn3; Fibronectin type III domain
      pfam15152
      Location:637678
      Kisspeptin
      pfam15905
      Location:888
      HMMR_N; Hyaluronan mediated motility receptor N-terminal
    4. XM_006504288.5XP_006504351.1  RIMS-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006504351.1

      UniProtKB/TrEMBL
      A0A571BDA2
      Conserved Domains (7) summary
      cd12012
      Location:11161177
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:12201280
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:192252
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      PHA03321
      Location:593737
      PHA03321; tegument protein VP11/12; Provisional
      cd00063
      Location:508594
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      TIGR02168
      Location:287
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00041
      Location:414481
      fn3; Fibronectin type III domain
    5. XM_006504295.5XP_006504358.1  RIMS-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A571BDA2
      Conserved Domains (7) summary
      cd12012
      Location:10671128
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:11711231
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:192252
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd00063
      Location:508594
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      TIGR02168
      Location:287
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00041
      Location:414481
      fn3; Fibronectin type III domain
      pfam15152
      Location:644685
      Kisspeptin
    6. XM_006504289.5XP_006504352.1  RIMS-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006504352.1

      UniProtKB/TrEMBL
      A0A571BDA2
      Conserved Domains (7) summary
      cd12012
      Location:11161177
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:12201280
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:192252
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      PHA03321
      Location:593737
      PHA03321; tegument protein VP11/12; Provisional
      cd00063
      Location:508594
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      TIGR02168
      Location:287
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00041
      Location:414481
      fn3; Fibronectin type III domain
    7. XM_006504293.4XP_006504356.1  RIMS-binding protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006504356.1

      UniProtKB/TrEMBL
      A0A571BDA2
      Conserved Domains (9) summary
      cd12012
      Location:11091170
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:12131273
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:185245
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      smart00060
      Location:314391
      FN3; Fibronectin type 3 domain
      PHA03321
      Location:586730
      PHA03321; tegument protein VP11/12; Provisional
      cd00063
      Location:501587
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:407474
      fn3; Fibronectin type III domain
      pfam15152
      Location:637678
      Kisspeptin
      pfam15905
      Location:888
      HMMR_N; Hyaluronan mediated motility receptor N-terminal
    8. XM_030254432.1XP_030110292.1  RIMS-binding protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A0G2JGW5
      Related
      ENSMUSP00000143725.2, ENSMUST00000196085.5
      Conserved Domains (8) summary
      cd12012
      Location:830891
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:934994
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:192252
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      PHA03321
      Location:593709
      PHA03321; tegument protein VP11/12; Provisional
      cd00063
      Location:508594
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      TIGR02168
      Location:287
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00041
      Location:414481
      fn3; Fibronectin type III domain
      pfam15152
      Location:644685
      Kisspeptin
    9. XM_017320871.2XP_017176360.1  RIMS-binding protein 2 isoform X7

      UniProtKB/Swiss-Prot
      B9EKT4, E9QPF5, Q80U40
      Conserved Domains (9) summary
      cd12012
      Location:879940
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:9831043
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:192252
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      smart00060
      Location:321398
      FN3; Fibronectin type 3 domain
      PHA03321
      Location:593737
      PHA03321; tegument protein VP11/12; Provisional
      cd00063
      Location:508594
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      TIGR02168
      Location:287
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00041
      Location:414481
      fn3; Fibronectin type III domain
      pfam15152
      Location:644685
      Kisspeptin
    10. XM_036165094.1XP_036020987.1  RIMS-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A571BDA2
      Conserved Domains (7) summary
      cd12012
      Location:11161177
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:12201280
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:192252
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      PHA03321
      Location:593737
      PHA03321; tegument protein VP11/12; Provisional
      cd00063
      Location:508594
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      TIGR02168
      Location:287
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00041
      Location:414481
      fn3; Fibronectin type III domain
    11. XM_006504294.5XP_006504357.1  RIMS-binding protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006504357.1

      UniProtKB/TrEMBL
      A0A571BDA2
      Related
      ENSMUSP00000158659.2, ENSMUST00000238334.2
      Conserved Domains (9) summary
      cd12012
      Location:11091170
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:12131273
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:185245
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      smart00060
      Location:314391
      FN3; Fibronectin type 3 domain
      PHA03321
      Location:586730
      PHA03321; tegument protein VP11/12; Provisional
      cd00063
      Location:501587
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:407474
      fn3; Fibronectin type III domain
      pfam15152
      Location:637678
      Kisspeptin
      pfam15905
      Location:888
      HMMR_N; Hyaluronan mediated motility receptor N-terminal
    12. XM_011240839.4XP_011239141.1  RIMS-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011239141.1

      UniProtKB/TrEMBL
      A0A571BDA2
      Conserved Domains (7) summary
      cd12012
      Location:11161177
      SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12013
      Location:12201280
      SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      cd12014
      Location:192252
      SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
      PHA03321
      Location:593737
      PHA03321; tegument protein VP11/12; Provisional
      cd00063
      Location:508594
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      TIGR02168
      Location:287
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00041
      Location:414481
      fn3; Fibronectin type III domain

    RNA

    1. XR_377055.5 RNA Sequence