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    Ints6 integrator complex subunit 6 [ Mus musculus (house mouse) ]

    Gene ID: 18130, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ints6provided by MGI
    Official Full Name
    integrator complex subunit 6provided by MGI
    Primary source
    MGI:MGI:1202397
    See related
    Ensembl:ENSMUSG00000035161 AllianceGenome:MGI:1202397
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HDB; DICE1; Ddx26; Notch2l; 2900075H24Rik
    Summary
    Predicted to be involved in snRNA 3'-end processing. Predicted to be located in actin cytoskeleton and nucleoplasm. Predicted to be part of integrator complex. Is expressed in neural retina and neural retinal epithelium. Orthologous to human INTS6 (integrator complex subunit 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 6.7), placenta adult (RPKM 5.3) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ints6 in Genome Data Viewer
    Location:
    14 D1; 14 33.23 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (62913774..62998617, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (62676325..62761163, complement)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Transgenic (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in snRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in snRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of integrator complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    integrator complex subunit 6
    Names
    DBI-1
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26
    int6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008715.2NP_032741.2  integrator complex subunit 6

      See identical proteins and their annotated locations for NP_032741.2

      Status: PROVISIONAL

      Source sequence(s)
      BC059263
      Consensus CDS
      CCDS27191.1
      UniProtKB/Swiss-Prot
      Q3TA02, Q61204, Q6PCM2, Q6PDL7, Q8BQZ7
      Related
      ENSMUSP00000086788.5, ENSMUST00000053959.7
      Conserved Domains (2) summary
      pfam15300
      Location:806864
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
      pfam13519
      Location:4131
      VWA_2; von Willebrand factor type A domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      62913774..62998617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315909.3XP_017171398.1  integrator complex subunit 6 isoform X3

      UniProtKB/Swiss-Prot
      Q6PCM2
      Conserved Domains (2) summary
      pfam15300
      Location:797855
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
      pfam13519
      Location:4131
      VWA_2; von Willebrand factor type A domain
    2. XM_006518680.5XP_006518743.1  integrator complex subunit 6 isoform X1

      See identical proteins and their annotated locations for XP_006518743.1

      Conserved Domains (2) summary
      pfam15300
      Location:807865
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
      pfam13519
      Location:4131
      VWA_2; von Willebrand factor type A domain
    3. XM_017315908.3XP_017171397.1  integrator complex subunit 6 isoform X1

      Conserved Domains (2) summary
      pfam15300
      Location:807865
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
      pfam13519
      Location:4131
      VWA_2; von Willebrand factor type A domain
    4. XM_011244985.4XP_011243287.1  integrator complex subunit 6 isoform X1

      See identical proteins and their annotated locations for XP_011243287.1

      Conserved Domains (2) summary
      pfam15300
      Location:807865
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
      pfam13519
      Location:4131
      VWA_2; von Willebrand factor type A domain
    5. XM_011244986.4XP_011243288.1  integrator complex subunit 6 isoform X2

      See identical proteins and their annotated locations for XP_011243288.1

      UniProtKB/Swiss-Prot
      Q3TA02, Q61204, Q6PCM2, Q6PDL7, Q8BQZ7
      Related
      ENSMUSP00000152954.2, ENSMUST00000223585.2
      Conserved Domains (2) summary
      pfam15300
      Location:806864
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
      pfam13519
      Location:4131
      VWA_2; von Willebrand factor type A domain
    6. XM_006518682.5XP_006518745.1  integrator complex subunit 6 isoform X3

      See identical proteins and their annotated locations for XP_006518745.1

      UniProtKB/Swiss-Prot
      Q6PCM2
      Conserved Domains (2) summary
      pfam15300
      Location:797855
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
      pfam13519
      Location:4131
      VWA_2; von Willebrand factor type A domain
    7. XM_036158504.1XP_036014397.1  integrator complex subunit 6 isoform X5

      Conserved Domains (1) summary
      pfam15300
      Location:618677
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
    8. XM_006518683.4XP_006518746.1  integrator complex subunit 6 isoform X4

      Conserved Domains (1) summary
      pfam15300
      Location:629687
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus