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    Zeb2 zinc finger E-box binding homeobox 2 [ Mus musculus (house mouse) ]

    Gene ID: 24136, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zeb2provided by MGI
    Official Full Name
    zinc finger E-box binding homeobox 2provided by MGI
    Primary source
    MGI:MGI:1344407
    See related
    Ensembl:ENSMUSG00000026872 AllianceGenome:MGI:1344407
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SIP1; Zfx1b; Zfhx1b; Zfxh1b; 9130203F04Rik; D130016B08Rik
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and R-SMAD binding activity. Involved in several processes, including melanocyte migration; positive regulation of cell differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including nervous system development; positive regulation of axonogenesis; and positive regulation of signal transduction. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Mowat-Wilson syndrome and T-cell adult acute lymphocytic leukemia. Human ortholog(s) of this gene implicated in Hirschsprung's disease and Mowat-Wilson syndrome. Orthologous to human ZEB2 (zinc finger E-box binding homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 11.4), CNS E18 (RPKM 9.1) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Zeb2 in Genome Data Viewer
    Location:
    2 B; 2 27.31 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (44873523..45007378, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (44983512..45117442, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene glycosyltransferase-like domain containing 1 Neighboring gene predicted gene, 39807 Neighboring gene STARR-seq mESC enhancer starr_04399 Neighboring gene centromere protein C1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:44816144-44816341 Neighboring gene STARR-seq mESC enhancer starr_04400 Neighboring gene microRNA 5129 Neighboring gene STARR-seq mESC enhancer starr_04403 Neighboring gene zinc finger E-box binding homeobox 2, opposite strand Neighboring gene STARR-positive B cell enhancer mm9_chr2:45049987-45050287 Neighboring gene STARR-seq mESC enhancer starr_04405 Neighboring gene STARR-seq mESC enhancer starr_04406 Neighboring gene VISTA enhancer mm1737 Neighboring gene STARR-seq mESC enhancer starr_04408 Neighboring gene viral integration site 1 Neighboring gene STARR-seq mESC enhancer starr_04409 Neighboring gene STARR-seq mESC enhancer starr_04410 Neighboring gene predicted gene 13479 Neighboring gene predicted gene, 30728

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0569

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in astrocyte activation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell proliferation in forebrain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within central nervous system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within collateral sprouting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within corpus callosum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within corticospinal tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in developmental pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fibroblast activation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hippocampus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mammillary axonal complex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in melanocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neural crest cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of JUN kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lens fiber cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of melanin biosynthetic process IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of melanocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of myofibroblast contraction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyroptotic inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of blood-brain barrier permeability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of melanosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of myofibroblast cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to oxygen-glucose deprivation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    zinc finger E-box-binding homeobox 2
    Names
    smad-interacting protein 1
    zinc finger homeobox protein 1b

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289521.2NP_001276450.1  zinc finger E-box-binding homeobox 2

      See identical proteins and their annotated locations for NP_001276450.1

      Status: VALIDATED

      Source sequence(s)
      AL929120, AL935127
      Consensus CDS
      CCDS16020.1
      UniProtKB/Swiss-Prot
      Q6P9M5, Q9R0G7
      UniProtKB/TrEMBL
      H9H9S3, Q3URW5
      Related
      ENSMUSP00000134747.2, ENSMUST00000177302.8
      Conserved Domains (4) summary
      cd00086
      Location:653695
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      sd00017
      Location:10011021
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:282304
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:296319
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001355288.2NP_001342217.1  zinc finger E-box-binding homeobox 2

      Status: VALIDATED

      Source sequence(s)
      AL929120, AL935127
      Consensus CDS
      CCDS16020.1
      UniProtKB/Swiss-Prot
      Q6P9M5, Q9R0G7
      UniProtKB/TrEMBL
      H9H9S3, Q3URW5
      Related
      ENSMUSP00000134849.2, ENSMUST00000176438.9
      Conserved Domains (4) summary
      cd00086
      Location:653695
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      sd00017
      Location:10011021
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:282304
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:296319
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001355289.2NP_001342218.1  zinc finger E-box-binding homeobox 2

      Status: VALIDATED

      Source sequence(s)
      AL929120, AL935127
      Consensus CDS
      CCDS16020.1
      UniProtKB/Swiss-Prot
      Q6P9M5, Q9R0G7
      UniProtKB/TrEMBL
      H9H9S3, Q3URW5
      Conserved Domains (4) summary
      cd00086
      Location:653695
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      sd00017
      Location:10011021
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:282304
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:296319
      zf-H2C2_2; Zinc-finger double domain
    4. NM_001355290.2NP_001342219.1  zinc finger E-box-binding homeobox 2

      Status: VALIDATED

      Source sequence(s)
      AL929120, AL935127
      Consensus CDS
      CCDS16020.1
      UniProtKB/Swiss-Prot
      Q6P9M5, Q9R0G7
      UniProtKB/TrEMBL
      H9H9S3, Q3URW5
      Conserved Domains (4) summary
      cd00086
      Location:653695
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      sd00017
      Location:10011021
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:282304
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:296319
      zf-H2C2_2; Zinc-finger double domain
    5. NM_001355291.2NP_001342220.1  zinc finger E-box-binding homeobox 2

      Status: VALIDATED

      Source sequence(s)
      AL929120, AL935127
      Consensus CDS
      CCDS16020.1
      UniProtKB/Swiss-Prot
      Q6P9M5, Q9R0G7
      UniProtKB/TrEMBL
      H9H9S3, Q3URW5
      Related
      ENSMUSP00000028229.8, ENSMUST00000028229.13
      Conserved Domains (4) summary
      cd00086
      Location:653695
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      sd00017
      Location:10011021
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:282304
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:296319
      zf-H2C2_2; Zinc-finger double domain
    6. NM_015753.5NP_056568.2  zinc finger E-box-binding homeobox 2

      See identical proteins and their annotated locations for NP_056568.2

      Status: VALIDATED

      Source sequence(s)
      AL929120, AL935127
      Consensus CDS
      CCDS16020.1
      UniProtKB/Swiss-Prot
      Q6P9M5, Q9R0G7
      UniProtKB/TrEMBL
      H9H9S3, Q3URW5
      Related
      ENSMUSP00000069685.5, ENSMUST00000068415.11
      Conserved Domains (4) summary
      cd00086
      Location:653695
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      sd00017
      Location:10011021
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:282304
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:296319
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_149354.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL935127
      Related
      ENSMUST00000153561.6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      44873523..45007378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)