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    Mipep mitochondrial intermediate peptidase [ Mus musculus (house mouse) ]

    Gene ID: 70478, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mipepprovided by MGI
    Official Full Name
    mitochondrial intermediate peptidaseprovided by MGI
    Primary source
    MGI:MGI:1917728
    See related
    Ensembl:ENSMUSG00000021993 AllianceGenome:MGI:1917728
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MIP; 5730405E07Rik
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in peptide metabolic process and protein processing involved in protein targeting to mitochondrion. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 31. Orthologous to human MIPEP (mitochondrial intermediate peptidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 35.6), adrenal adult (RPKM 9.5) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Mipep in Genome Data Viewer
    Location:
    14 D1; 14 31.95 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (61022011..61142930)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (60784562..60905481)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36864 Neighboring gene predicted gene, 34997 Neighboring gene C1q and tumor necrosis factor related protein 9 Neighboring gene mitochondrial intermediate peptidase, opposite strand Neighboring gene STARR-positive B cell enhancer mm9_chr14:61418588-61418889 Neighboring gene STARR-seq mESC enhancer starr_36865 Neighboring gene STARR-seq mESC enhancer starr_36867 Neighboring gene STARR-seq mESC enhancer starr_36869 Neighboring gene tumor necrosis factor receptor superfamily, member 19 Neighboring gene STARR-seq mESC enhancer starr_36870 Neighboring gene VISTA enhancer mm7 Neighboring gene STARR-seq mESC enhancer starr_36873 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:61665054-61665237 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:61675420-61675649 Neighboring gene predicted gene, 41167 Neighboring gene predicted gene, 41168

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in peptide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein processing involved in protein targeting to mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitochondrial intermediate peptidase
    NP_081712.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027436.3NP_081712.2  mitochondrial intermediate peptidase precursor

      See identical proteins and their annotated locations for NP_081712.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AI606287, AK017491, BE995975, CA460475
      Consensus CDS
      CCDS49517.1
      UniProtKB/Swiss-Prot
      A6H611, Q2YD79, Q3UJJ3, Q80VA3
      Related
      ENSMUSP00000069840.8, ENSMUST00000063562.9
      Conserved Domains (2) summary
      cd06457
      Location:62695
      M3A_MIP; Peptidase M3 mitochondrial intermediate peptidase (MIP)
      COG0339
      Location:71691
      Dcp; Zn-dependent oligopeptidase [Posttranslational modification, protein turnover, chaperones]

    RNA

    1. NR_040642.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an additional exon in the 3' end, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC122477, AC151835
      Related
      ENSMUST00000225506.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      61022011..61142930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004938443.1 RNA Sequence