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    Bcl7b B cell CLL/lymphoma 7B [ Mus musculus (house mouse) ]

    Gene ID: 12054, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bcl7bprovided by MGI
    Official Full Name
    B cell CLL/lymphoma 7Bprovided by MGI
    Primary source
    MGI:MGI:1332238
    See related
    Ensembl:ENSMUSG00000029681 AllianceGenome:MGI:1332238
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be involved in Wnt signaling pathway; apoptotic process; and cell differentiation. Part of SWI/SNF complex. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and skin. Orthologous to human BCL7B (BAF chromatin remodeling complex subunit BCL7B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 22.4), thymus adult (RPKM 17.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bcl7b in Genome Data Viewer
    Location:
    5 G2; 5 75.04 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135197226..135210706)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135168372..135181852)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14566 Neighboring gene MLX interacting protein-like Neighboring gene STARR-positive B cell enhancer ABC_E855 Neighboring gene STARR-positive B cell enhancer ABC_E280 Neighboring gene transducin (beta)-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E6386 Neighboring gene STARR-seq mESC enhancer starr_14571 Neighboring gene STARR-positive B cell enhancer ABC_E2767 Neighboring gene STARR-seq mESC enhancer starr_14572 Neighboring gene bromodomain adjacent to zinc finger domain, 1B Neighboring gene frizzled class receptor 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular profiling of mouse lung tumors: association with tumor progression, lung development, and human lung adenocarcinomas. Bonner AE, et al. Oncogene, 2004 Feb 5. PMID 14647414
    2. The BCL7 gene family: deletion of BCL7B in Williams syndrome. Jadayel DM, et al. Gene, 1998 Dec 11. PMID 9931421
    3. The SWI/SNF subunit Bcl7a contributes to motor coordination and Purkinje cell function. Wischhof L, et al. Sci Rep, 2017 Dec 6. PMID 29213114, Free PMC Article
    4. Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. Kadoch C, et al. Nat Genet, 2013 Jun. PMID 23644491, Free PMC Article
    5. BCL7A-containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation. Wischhof L, et al. EMBO J, 2022 Dec 1. PMID 36305367, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of double-strand break repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of stem cell population maintenance NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of G0 to G1 transition NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of G1/S transition of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of mitotic metaphase/anaphase transition NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of nucleotide-excision repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GBAF complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of SWI/SNF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SWI/SNF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SWI/SNF complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in chromatin NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    B-cell CLL/lymphoma 7 protein family member B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009745.2 → NP_033875.2  B-cell CLL/lymphoma 7 protein family member B

      See identical proteins and their annotated locations for NP_033875.2

      Status: VALIDATED

      Source sequence(s)
      AK131643, BY087167, CX244204
      Consensus CDS
      CCDS51660.1
      UniProtKB/Swiss-Prot
      O89022, Q3TV31, Q3U2W0, Q921K9
      Related
      ENSMUSP00000031692.6, ENSMUST00000031692.12
      Conserved Domains (1) summary
      pfam04714
      Location:4 → 50
      BCL_N; BCL7, N-terminal conserver region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      135197226..135210706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q921K9.1 GenPept UniProtKB/Swiss-Prot:Q921K9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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