Chst11 carbohydrate sulfotransferase 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chst11provided by MGI
Official Full Name: carbohydrate sulfotransferase 11provided by MGI
Primary source: MGI:MGI:1927166
See related: Ensembl:ENSMUSG00000034612 AllianceGenome:MGI:1927166
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C4s; C4ST; C4ST1; C4ST-1; 1110020P09Rik
Summary: Enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity. Acts upstream of or within several processes, including chondroitin sulfate biosynthetic process; post-anal tail morphogenesis; and skeletal system development. Predicted to be located in Golgi membrane. Is expressed in several structures, including alimentary system; central nervous system; ear; heart; and skeletal system. Orthologous to human CHST11 (carbohydrate sulfotransferase 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in ovary adult (RPKM 37.7), adrenal adult (RPKM 14.0) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 40.66 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (82820274..83031738)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (82984440..83195904)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wnt/beta-catenin signaling controls C4ST-1 gene expression through histone deacetylase. C4ST-1 expression is regulated through DNA sequence located at -394 and -387 in its promoter region.
Title: Histone deacetylase-mediated regulation of chondroitin 4-O-sulfotransferase-1 (Chst11) gene expression by Wnt/β-catenin signaling.
Deficiency in Chst11 did not influence neural stem cell proliferation, migration or differentiation.
Title: Dermatan sulfotransferase Chst14/D4st1, but not chondroitin sulfotransferase Chst11/C4st1, regulates proliferation and neurogenesis of neural progenitor cells.
these results suggested that C4ST-1 and ChGn-2 may be involved in the elongation of chondroitin sulfate chains in the arterial wall during the progression of atherosclerosis.
Title: Correlation of C4ST-1 and ChGn-2 expression with chondroitin sulfate chain elongation in atherosclerosis.
Forced expression of C4ST-1 in L-Wnt-3a cells inhibited diffusion of Wnt-3a due to structural alterations in CS chains mediated by C4ST-1.
Title: Down-regulation of chondroitin 4-O-sulfotransferase-1 by Wnt signaling triggers diffusion of Wnt-3a.
expression of the Serglycincore protein, chondroitin 4-sulfotransferase (C4ST)-1, and GalNAc(4S)-6-O-sulfotransferase (GalNAc4S6ST) are closely linked to mast cell maturation
Title: Mast cell differentiation and activation is closely linked to expression of genes coding for the serglycin proteoglycan core protein and a distinct set of chondroitin sulfate and heparin sulfotransferases.
CS-E-like structures synthesized by C4ST-1 participate in Wnt-3a signaling and modulate the physiological events caused by Wnt-3a signals.
Title: Chondroitin 4-O-sulfotransferase-1 modulates Wnt-3a signaling through control of E disaccharide expression of chondroitin sulfate.
a gene was identified for Chondroitin-4-sulfotransferase and displays a highly specific temporal and spatial expression pattern during mouse embryogenesis
Title: A high-throughput induction gene trap approach defines C4ST as a target of BMP signaling.
chondroitin 4-O-sulfation by C4st1 is required for proper chondroitin sulfate localization, modulation of distinct signaling pathways and cartilage growth plate morphogenesis
Title: Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis.
results suggest that C4ST-1 regulates the expression of the E disaccharide unit and the length of CS chains, the features that facilitate infection of cells by HSV-1
Title: Chondroitin 4-O-sulfotransferase-1 regulates E disaccharide expression of chondroitin sulfate required for herpes simplex virus infectivity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (1)
Gene trapped (1) 1 citation
Targeted (2) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:532265

Chst11 (e-PCR), detects polymorphism
- UniSTS:532265

Chst11 (e-PCR), detects polymorphism
- UniSTS:516432

D10Mit160 (e-PCR), detects polymorphism
- UniSTS:126064

D10Mit227 (e-PCR), detects polymorphism
- UniSTS:126130

RH135904 (e-PCR)
- UniSTS:209902

NoName (e-PCR)
- UniSTS:492271

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables chondroitin 4-sulfotransferase activity	IEA Inferred from Electronic Annotation more info
enables chondroitin 4-sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables dermatan 4-sulfotransferase	IEA Inferred from Electronic Annotation more info
enables dermatan 4-sulfotransferase	ISO Inferred from Sequence Orthology more info
enables sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carbohydrate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chondrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chondroitin sulfate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chondroitin sulfate biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chondroitin sulfate biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chondroitin sulfate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic digit morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic limb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within polysaccharide localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-anal tail morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: carbohydrate sulfotransferase 11

Names: C4S-1; chondroitin 4; chondroitin 4-O-sulfotransferase 1; chondroitin 4-sulfotransferase 1

NP_067414.2

EC 2.8.2.5

XP_006513971.1

EC 2.8.2.5

XP_006513972.1

EC 2.8.2.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429269.1 → NP_001416198.1 carbohydrate sulfotransferase 11

Status: VALIDATED

Source sequence(s)

AC102114, AC155938, AC159149

UniProtKB/TrEMBL

B7ZMT9
NM_021439.4 → NP_067414.2 carbohydrate sulfotransferase 11

See identical proteins and their annotated locations for NP_067414.2

Status: VALIDATED

Source sequence(s)

AC102114, AC155938, AC159149

Consensus CDS

CCDS24074.1

UniProtKB/Swiss-Prot

Q9JJS2, Q9JME2

UniProtKB/TrEMBL

B9EHC3

Related

ENSMUSP00000045349.8, ENSMUST00000040110.8

Conserved Domains (1) summary

pfam03567
Location:113 → 343

Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

82820274..83031738

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513909.4 → XP_006513972.1 carbohydrate sulfotransferase 11 isoform X2

Conserved Domains (1) summary

pfam03567
Location:108 → 338

Sulfotransfer_2; Sulfotransferase family
XM_006513908.5 → XP_006513971.1 carbohydrate sulfotransferase 11 isoform X1

Conserved Domains (1) summary

pfam03567
Location:112 → 342

Sulfotransfer_2; Sulfotransferase family