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    Rbm27 RNA binding motif protein 27 [ Mus musculus (house mouse) ]

    Gene ID: 225432, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rbm27provided by MGI
    Official Full Name
    RNA binding motif protein 27provided by MGI
    Primary source
    MGI:MGI:2147194
    See related
    Ensembl:ENSMUSG00000024491 AllianceGenome:MGI:2147194
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Psc1; mKIAA1311; A730010I06
    Summary
    Predicted to enable RNA binding activity. Predicted to be located in cytoplasm and nuclear speck. Predicted to be active in nucleus. Is expressed in several structures, including blastocyst; brain; lung; and sensory organ. Orthologous to human RBM27 (RNA binding motif protein 27). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 9.4), CNS E11.5 (RPKM 5.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rbm27 in Genome Data Viewer
    Location:
    18 B3; 18 22.45 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (42408386..42474607)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (42275205..42341542)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene leucyl-tRNA synthetase 1 Neighboring gene ribosomal protein S19, pseudogene 4 Neighboring gene STARR-positive B cell enhancer ABC_E494 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:42434622-42434731 Neighboring gene STARR-positive B cell enhancer ABC_E495 Neighboring gene predicted gene 4013 Neighboring gene STARR-seq mESC enhancer starr_44436 Neighboring gene STARR-seq mESC enhancer starr_44438 Neighboring gene STARR-seq mESC enhancer starr_44439 Neighboring gene POU domain, class 4, transcription factor 3 Neighboring gene predicted gene, 31438

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A family of RS domain proteins with novel subcellular localization and trafficking. Kavanagh SJ, et al. Nucleic Acids Res, 2005. PMID 15741184, Free PMC Article
    2. Transient pluripotent cell populations during primitive ectoderm formation: correlation of in vivo and in vitro pluripotent cell development. Pelton TA, et al. J Cell Sci, 2002 Jan 15. PMID 11839785
    3. A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Jones MR, et al. Front Genet, 2018. PMID 30728831, Free PMC Article
    4. Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue. Chavez JD, et al. Cell Syst, 2018 Jan 24. PMID 29199018, Free PMC Article
    5. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 27
    Names
    peri implantation stem cell 1
    peri-implantation stem cell protein 1
    periimplantation stem cell 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001408209.1 → NP_001395138.1  RNA-binding protein 27 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125110
      UniProtKB/Swiss-Prot
      E9QM85, Q5SFM8, Q6ZPT9, Q7TQK8, Q8C2X5, Q8C9A5
      Related
      ENSMUSP00000158063.2, ENSMUST00000236240.2

    2. NM_001408210.1 → NP_001395139.1  RNA-binding protein 27 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC125110

    3. NM_001408211.1 → NP_001395140.1  RNA-binding protein 27 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC125110

    4. NM_172626.3 → NP_766214.2  RNA-binding protein 27 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125110
      Consensus CDS
      CCDS50267.1
      UniProtKB/Swiss-Prot
      Q5SFM8
      Related
      ENSMUSP00000089540.6, ENSMUST00000091920.6
      Conserved Domains (4) summary
      pfam00642
      Location:277 → 299
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam16046
      Location:694 → 828
      FAM76; FAM76 protein
      cl02562
      Location:7 → 72
      PWI; PWI domain
      cl17169
      Location:544 → 619
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      42408386..42474607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525864.4 → XP_006525927.1  RNA-binding protein 27 isoform X2

      Conserved Domains (6) summary
      cd12517
      Location:599 → 674
      RRM_RBM27; RNA recognition motif of vertebrate RNA-binding protein 27 (RBM27)
      pfam00642
      Location:277 → 299
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam15991
      Location:661 → 773
      G_path_suppress; G-protein pathway suppressor
      cl02562
      Location:7 → 72
      PWI; PWI domain
      cl17169
      Location:931 → 973
      RRM_SF; RNA recognition motif (RRM) superfamily
      cl19219
      Location:763 → 844
      FapA; Flagellar Assembly Protein A

    2. XM_017317887.3 → XP_017173376.1  RNA-binding protein 27 isoform X3

      Conserved Domains (4) summary
      PRK03918
      Location:708 → 839
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam15991
      Location:563 → 727
      G_path_suppress; G-protein pathway suppressor
      cl02562
      Location:7 → 72
      PWI; PWI domain
      cl17169
      Location:501 → 576
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SFM8.3 GenPept UniProtKB/Swiss-Prot:Q5SFM8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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