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    DYNC1LI1 dynein cytoplasmic 1 light intermediate chain 1 [ Homo sapiens (human) ]

    Gene ID: 51143, updated on 3-Dec-2024

    Summary

    Official Symbol
    DYNC1LI1provided by HGNC
    Official Full Name
    dynein cytoplasmic 1 light intermediate chain 1provided by HGNC
    Primary source
    HGNC:HGNC:18745
    See related
    Ensembl:ENSG00000144635 MIM:615890; AllianceGenome:HGNC:18745
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LIC1; DLC-A; DLIC-1; DNCLI1
    Summary
    The protein encoded by this gene belongs to light intermediate subunit family, whose members are components of the multiprotein cytoplasmic dynein complex, which is involved in intracellular trafficking and chromosome segregation during mitosis. The protein plays a role in moving the spindle assembly checkpoint (SAC) from kinetochores to spindle poles. The protein may also mediate binding to other cargo molecules to facilitate intracellular vesicle trafficking. [provided by RefSeq, Jul 2016]
    Expression
    Ubiquitous expression in testis (RPKM 27.3), heart (RPKM 19.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See DYNC1LI1 in Genome Data Viewer
    Location:
    3p22.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (32525974..32570858, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (32522924..32567802, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (32567466..32612350, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene microRNA 548ay Neighboring gene ribosomal protein L31 pseudogene 18 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:32611558-32612343 Neighboring gene uncharacterized LOC124906226 Neighboring gene POLE4 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr is identified to have a physical interaction with dynein, cytoplasmic 1, light intermediate chain 1 (DYNC1LI1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    capsid gag HIV-1 CA uncoating is delayed in the presence of ciliobrevin D, a specific inhibitor of dynein-mediated motor function, indicating that dynein is involved in CA uncoating in cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10219

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dynein heavy chain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables molecular adaptor activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cytoplasmic dynein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endocytic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ficolin-1-rich granule membrane TAS
    Traceable Author Statement
    more info
     
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 
    is_active_in microtubule IC
    Inferred by Curator
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
     
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cytoplasmic dynein 1 light intermediate chain 1
    Names
    dynein light chain A
    dynein light intermediate chain 1, cytosolic
    dynein, cytoplasmic, light intermediate polypeptide 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051046.1 RefSeqGene

      Range
      5067..49951
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001329135.2NP_001316064.1  cytoplasmic dynein 1 light intermediate chain 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two consecutive alternate exons in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK074348
      Consensus CDS
      CCDS87058.1
      UniProtKB/TrEMBL
      B4DDM4, E9PHI6
      Related
      ENSP00000407279.2, ENST00000432458.6
      Conserved Domains (1) summary
      pfam05783
      Location:43403
      DLIC; Dynein light intermediate chain (DLIC)
    2. NM_016141.4NP_057225.2  cytoplasmic dynein 1 light intermediate chain 1 isoform 1

      See identical proteins and their annotated locations for NP_057225.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK074348
      Consensus CDS
      CCDS2654.1
      UniProtKB/Swiss-Prot
      A2RRG7, Q53HC8, Q53HK7, Q9Y6G9
      Related
      ENSP00000273130.4, ENST00000273130.9
      Conserved Domains (1) summary
      pfam05783
      Location:43517
      DLIC; Dynein light intermediate chain (DLIC)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      32525974..32570858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448246.1XP_047304202.1  cytoplasmic dynein 1 light intermediate chain 1 isoform X1

      UniProtKB/TrEMBL
      B3KM42, B4DDM4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      32522924..32567802 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346721.1XP_054202696.1  cytoplasmic dynein 1 light intermediate chain 1 isoform X1

      UniProtKB/TrEMBL
      B3KM42, B4DDM4