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    SPATA16 spermatogenesis associated 16 [ Homo sapiens (human) ]

    Gene ID: 83893, updated on 3-Dec-2024

    Summary

    Official Symbol
    SPATA16provided by HGNC
    Official Full Name
    spermatogenesis associated 16provided by HGNC
    Primary source
    HGNC:HGNC:29935
    See related
    Ensembl:ENSG00000144962 MIM:609856; AllianceGenome:HGNC:29935
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPGF6; NYD-SP12
    Summary
    This gene encodes a testis-specific protein that belongs to the tetratricopeptide repeat-like superfamily. The encoded protein localizes to the Golgi apparatus and may play a role in spermatogenesis. [provided by RefSeq, May 2010]
    Expression
    Restricted expression toward testis (RPKM 29.2) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SPATA16 in Genome Data Viewer
    Location:
    3q26.31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (172889357..173141235, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (175675113..175927030, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (172607147..172859025, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986052 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:172571656-172572164 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:172572165-172572672 Neighboring gene NANOG hESC enhancer GRCh37_chr3:172579049-172579639 Neighboring gene MMACHC pseudogene 1 Neighboring gene MPRA-validated peak4926 silencer Neighboring gene uncharacterized LOC105374221 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC105374220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:172858511-172859012 Neighboring gene uncharacterized LOC105374224 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:172963126-172963695 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:172971223-172971761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:173004473-173004973 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:173070760-173071467 Neighboring gene uncharacterized LOC124909458

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Globozoospermia
    MedGen: C0403825 OMIM: 102530 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide association meta-analysis of preschool internalizing problems.
    EBI GWAS Catalog
    A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in spermatid development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    spermatogenesis-associated protein 16
    Names
    testicular tissue protein Li 185
    testis development protein NYD-SP12
    testis-specific Golgi protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021422.1 RefSeqGene

      Range
      5034..256912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_031955.6NP_114161.3  spermatogenesis-associated protein 16

      See identical proteins and their annotated locations for NP_114161.3

      Status: REVIEWED

      Source sequence(s)
      AC063933, BC034496, BI829426
      Consensus CDS
      CCDS3221.1
      UniProtKB/Swiss-Prot
      Q0R0N4, Q0R0S0, Q0R0W2, Q0R129, Q0R131, Q0R140, Q0R1B8, Q0R1G5, Q0R1I2, Q0R1J6, Q0R1S4, Q0R202, Q0R280, Q0R2F8, Q0R2N6, Q0R2N7, Q0R2R0, Q0R2R1, Q0R2S3, Q0R2S4, Q0R2S5, Q0R2T4, Q0R2T7, Q0R2U2, Q0R2U8, Q0R2U9, Q0R2V5, Q0R2V7, Q8NE67, Q9BXB7
      UniProtKB/TrEMBL
      A0A140VJV8, B3KS78
      Related
      ENSP00000341765.3, ENST00000351008.4
      Conserved Domains (2) summary
      sd00006
      Location:217257
      TPR; TPR repeat [structural motif]
      pfam15015
      Location:6567
      NYD-SP12_N; Spermatogenesis-associated, N-terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      172889357..173141235 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006713778.4XP_006713841.1  spermatogenesis-associated protein 16 isoform X1

      UniProtKB/TrEMBL
      B3KS78
      Conserved Domains (2) summary
      sd00006
      Location:217257
      TPR; TPR repeat [structural motif]
      pfam15015
      Location:6529
      NYD-SP12_N; Spermatogenesis-associated, N-terminal
    2. XM_017007308.3XP_016862797.1  spermatogenesis-associated protein 16 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      175675113..175927030 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348065.1XP_054204040.1  spermatogenesis-associated protein 16 isoform X1

      UniProtKB/TrEMBL
      B3KS78
    2. XM_054348066.1XP_054204041.1  spermatogenesis-associated protein 16 isoform X2