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    Defb34 defensin beta 34 [ Mus musculus (house mouse) ]

    Gene ID: 360211, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Defb34provided by MGI
    Official Full Name
    defensin beta 34provided by MGI
    Primary source
    MGI:MGI:2672979
    See related
    Ensembl:ENSMUSG00000052554 AllianceGenome:MGI:2672979
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BD-34
    Summary
    Predicted to enable CCR2 chemokine receptor binding activity; heparin binding activity; and lipopolysaccharide binding activity. Predicted to be involved in defense response to bacterium and innate immune response. Predicted to be located in membrane; microvesicle; and nucleus. Orthologous to human DEFB106A (defensin beta 106A) and DEFB106B (defensin beta 106B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Defb34 in Genome Data Viewer
    Location:
    8 A1.3; 8 10.35 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (19173744..19176556)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (19123728..19126540)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene defensin beta 39 Neighboring gene STARR-seq mESC enhancer starr_20860 Neighboring gene defensin beta 12 Neighboring gene sperm associated antigen 11B Neighboring gene sperm associated antigen 11A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification on mouse chromosome 8 of new beta-defensin genes with regionally specific expression in the male reproductive organ. Zaballos A, et al. J Biol Chem, 2004 Mar 26. PMID 14718547
    2. Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome. Amid C, et al. BMC Genomics, 2009 Dec 15. PMID 20003482, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CCR2 chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipopolysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microvesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    beta-defensin 34

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183035.1 → NP_898856.1  beta-defensin 34 precursor

      See identical proteins and their annotated locations for NP_898856.1

      Status: VALIDATED

      Source sequence(s)
      AJ578469
      Consensus CDS
      CCDS52497.1
      UniProtKB/Swiss-Prot
      Q7TNV8
      Related
      ENSMUSP00000064554.4, ENSMUST00000064475.4
      Conserved Domains (1) summary
      pfam13841
      Location:27 → 56
      Defensin_beta_2; Beta defensin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      19173744..19176556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312869.1 → XP_017168358.1  beta-defensin 34 isoform X1

      Conserved Domains (1) summary
      pfam13841
      Location:33 → 62
      Defensin_beta_2; Beta defensin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TNV8.1 GenPept UniProtKB/Swiss-Prot:Q7TNV8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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