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    STT3B STT3 oligosaccharyltransferase complex catalytic subunit B [ Homo sapiens (human) ]

    Gene ID: 201595, updated on 9-Dec-2024

    Summary

    Official Symbol
    STT3Bprovided by HGNC
    Official Full Name
    STT3 oligosaccharyltransferase complex catalytic subunit Bprovided by HGNC
    Primary source
    HGNC:HGNC:30611
    See related
    Ensembl:ENSG00000163527 MIM:608605; AllianceGenome:HGNC:30611
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIMP; CDG1X; STT3-B
    Summary
    The protein encoded by this gene is a catalytic subunit of a protein complex that transfers oligosaccharides onto asparagine residues. Defects in this gene are a cause of congenital disorder of glycosylation Ix (CDG1X). [provided by RefSeq, Jun 2014]
    Expression
    Ubiquitous expression in testis (RPKM 42.8), thyroid (RPKM 37.3) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See STT3B in Genome Data Viewer
    Location:
    3p23
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (31532925..31637616)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (31535391..31640070)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (31574417..31679108)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2436 Neighboring gene H3 histone pseudogene 11 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:31398204-31399403 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:31418321-31419520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19628 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:31453982-31455181 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14159 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:31490161-31490339 Neighboring gene Sharpr-MPRA regulatory region 4459 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_69494 Neighboring gene THRAP3 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:31568343-31568843 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14161 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19630 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14163 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19629 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:31576589-31577090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:31577091-31577590 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_69540 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_69549 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_69593 Neighboring gene NANOG hESC enhancer GRCh37_chr3:31720020-31720521 Neighboring gene uncharacterized LOC124909360 Neighboring gene OSBPL10 antisense RNA 1 Neighboring gene oxysterol binding protein like 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    STT3B-congenital disorder of glycosylation
    MedGen: C2931007 OMIM: 615597 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ90106

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables dolichyl-diphosphooligosaccharide-protein glycotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dolichyl-diphosphooligosaccharide-protein glycotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables dolichyl-diphosphooligosaccharide-protein glycotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
    Names
    STT3, subunit of the oligosaccharyltransferase complex, homolog B
    STT3B, catalytic subunit of the oligosaccharyltransferase complex
    STT3B, subunit of the oligosaccharyltransferase complex (catalytic)
    dolichyl-diphosphooligosaccharide protein glycotransferase
    homolog of yeast STT3
    oligosaccharyl transferase subunit STT3B
    source of immunodominant MHC-associated peptides homolog
    NP_849193.1
    XP_011531767.1
    XP_016861347.1
    XP_054201614.1
    XP_054201615.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034164.1 RefSeqGene

      Range
      5425..110116
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_178862.3NP_849193.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

      See identical proteins and their annotated locations for NP_849193.1

      Status: REVIEWED

      Source sequence(s)
      AC104643, AI914841, AK075380, AY074880, HY015137, HY039873
      Consensus CDS
      CCDS2650.1
      UniProtKB/Swiss-Prot
      Q8TCJ2, Q96JZ4, Q96KY7
      Related
      ENSP00000295770.2, ENST00000295770.4
      Conserved Domains (1) summary
      pfam02516
      Location:71563
      STT3; Oligosaccharyl transferase STT3 subunit

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      31532925..31637616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011533465.2XP_011531767.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B isoform X2

      See identical proteins and their annotated locations for XP_011531767.1

      Conserved Domains (1) summary
      pfam02516
      Location:71442
      STT3; Oligosaccharyl transferase STT3 subunit
    2. XM_017005858.2XP_016861347.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B isoform X1

      Related
      ENSP00000520729.1, ENST00000462235.6
      Conserved Domains (1) summary
      pfam02516
      Location:1417
      STT3; Oligosaccharyl transferase STT3 subunit

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      31535391..31640070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345640.1XP_054201615.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B isoform X2

    2. XM_054345639.1XP_054201614.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B isoform X1