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    Lamb3 laminin, beta 3 [ Mus musculus (house mouse) ]

    Gene ID: 16780, updated on 4-Jan-2025

    Summary

    Official Symbol
    Lamb3provided by MGI
    Official Full Name
    laminin, beta 3provided by MGI
    Primary source
    MGI:MGI:99915
    See related
    Ensembl:ENSMUSG00000026639 AllianceGenome:MGI:99915
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be an extracellular matrix structural constituent. Acts upstream of or within brown fat cell differentiation. Located in basement membrane. Part of laminin-5 complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Used to study junctional epidermolysis bullosa Herlitz type and junctional epidermolysis bullosa non-Herlitz type. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1A; junctional epidermolysis bullosa; and lung small cell carcinoma. Orthologous to human LAMB3 (laminin subunit beta 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in colon adult (RPKM 41.0), lung adult (RPKM 26.5) and 11 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Lamb3 in Genome Data Viewer
    Location:
    1 H6; 1 97.71 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (192976661..193026186)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (193294353..193343878)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03470 Neighboring gene STARR-positive B cell enhancer ABC_E8 Neighboring gene hydroxysteroid 11-beta dehydrogenase 1 Neighboring gene STARR-seq mESC enhancer starr_03471 Neighboring gene STARR-positive B cell enhancer mm9_chr1:195090138-195090438 Neighboring gene G0/G1 switch gene 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:195164577-195164848 Neighboring gene predicted gene, 51741 Neighboring gene calcium/calmodulin-dependent protein kinase I gamma Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:195273620-195273803 Neighboring gene VISTA enhancer mm935 Neighboring gene STARR-seq mESC enhancer starr_03474 Neighboring gene predicted gene, 38022

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in animal organ morphogenesis  
    involved_in axon guidance  
    involved_in basement membrane assembly  
    acts_upstream_of_or_within brown fat cell differentiation PubMed 
    involved_in cell adhesion  
    involved_in cell migration  
    involved_in endodermal cell differentiation  
    involved_in substrate adhesion-dependent cell spreading  
    involved_in tissue development  
    Component Evidence Code Pubs
    located_in basement membrane PubMed 
    located_in basement membrane PubMed 
    located_in collagen-containing extracellular matrix PubMed 
    located_in extracellular region  
    part_of laminin complex  
    part_of laminin-5 complex PubMed 

    General protein information

    Preferred Names
    laminin subunit beta-3
    Names
    epiligrin subunit bata
    kalinin B1 chain
    kalinin subunit beta
    laminin-5 subunit beta
    nicein subunit beta
    nicein, 125kD
    nicein, 125kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277928.1NP_001264857.1  laminin subunit beta-3 precursor

      See identical proteins and their annotated locations for NP_001264857.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC022675
      Consensus CDS
      CCDS15637.1
      UniProtKB/Swiss-Prot
      Q61087, Q91V90
      Related
      ENSMUSP00000123875.2, ENSMUST00000159955.2
      Conserved Domains (5) summary
      smart00180
      Location:478528
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:530579
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      TIGR02168
      Location:8301161
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00053
      Location:376425
      Laminin_EGF; Laminin EGF domain
      cl02806
      Location:20248
      Laminin_N; Laminin N-terminal (Domain VI)
    2. NM_008484.2NP_032510.2  laminin subunit beta-3 precursor

      See identical proteins and their annotated locations for NP_032510.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC022675, AK078970, BY098011, BY101470, BY248755, CK023039, CX237661
      Consensus CDS
      CCDS15637.1
      UniProtKB/Swiss-Prot
      Q61087, Q91V90
      Related
      ENSMUSP00000016315.10, ENSMUST00000016315.16
      Conserved Domains (5) summary
      smart00180
      Location:478528
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:530579
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      TIGR02168
      Location:8301161
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00053
      Location:376425
      Laminin_EGF; Laminin EGF domain
      cl02806
      Location:20248
      Laminin_N; Laminin N-terminal (Domain VI)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      192976661..193026186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497233.2XP_006497296.1  laminin subunit beta-3 isoform X1

      See identical proteins and their annotated locations for XP_006497296.1

      UniProtKB/Swiss-Prot
      Q61087, Q91V90
      Related
      ENSMUSP00000142053.2, ENSMUST00000194677.6
      Conserved Domains (5) summary
      smart00180
      Location:478528
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:530579
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      TIGR02168
      Location:8301161
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00053
      Location:376425
      Laminin_EGF; Laminin EGF domain
      cl02806
      Location:20248
      Laminin_N; Laminin N-terminal (Domain VI)
    2. XM_006497232.1XP_006497295.1  laminin subunit beta-3 isoform X1

      See identical proteins and their annotated locations for XP_006497295.1

      UniProtKB/Swiss-Prot
      Q61087, Q91V90
      Conserved Domains (5) summary
      smart00180
      Location:478528
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:530579
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      TIGR02168
      Location:8301161
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00053
      Location:376425
      Laminin_EGF; Laminin EGF domain
      cl02806
      Location:20248
      Laminin_N; Laminin N-terminal (Domain VI)
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