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    Chadl chondroadherin-like [ Mus musculus (house mouse) ]

    Gene ID: 214685, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Chadlprovided by MGI
    Official Full Name
    chondroadherin-likeprovided by MGI
    Primary source
    MGI:MGI:3036284
    See related
    Ensembl:ENSMUSG00000063765 AllianceGenome:MGI:3036284
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D930017K21Rik
    Summary
    Predicted to enable collagen binding activity and collagen fibril binding activity. Involved in negative regulation of chondrocyte differentiation. Located in collagen-containing extracellular matrix. Is expressed in ureteric tip. Orthologous to human CHADL (chondroadherin like). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Note: We previously annotated two pseudogenes overlapping this gene, based on predictions from pseudogene.org. Our curation indicates that this locus is protein-coding. [28 Nov 2011]
    Expression
    Broad expression in limb E14.5 (RPKM 16.9), adrenal adult (RPKM 6.8) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Chadl in Genome Data Viewer
    Location:
    15 E1; 15 38.2 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (81570366..81581564, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (81686166..81697373, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene E1A binding protein p300 Neighboring gene predicted gene, 22067 Neighboring gene STARR-positive B cell enhancer ABC_E2446 Neighboring gene L3MBTL2 polycomb repressive complex 1 subunit Neighboring gene TM2 domain containing 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_39263 Neighboring gene RAN GTPase activating protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E1915 Neighboring gene zinc finger CCCH type containing 7B Neighboring gene STARR-seq mESC enhancer starr_39269

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Engineered viruses to select genes encoding secreted and membrane-bound proteins in mammalian cells. Moffatt P, et al. Nucleic Acids Res, 2002 Oct 1. PMID 12364608, Free PMC Article
    2. The novel small leucine-rich protein chondroadherin-like (CHADL) is expressed in cartilage and modulates chondrocyte differentiation. Tillgren V, et al. J Biol Chem, 2015 Jan 9. PMID 25451920, Free PMC Article
    3. Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Rutledge EA, et al. Development, 2017 Sep 1. PMID 28705898, Free PMC Article
    4. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables collagen binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables collagen fibril binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables collagen fibril binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of chondrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of collagen fibril organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of collagen fibril organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    chondroadherin-like protein
    Names
    chondroadherin pseudogene
    leucine rich repeat containing 15 pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164320.1 → NP_001157792.1  chondroadherin-like protein precursor

      See identical proteins and their annotated locations for NP_001157792.1

      Status: PROVISIONAL

      Source sequence(s)
      AC102262
      Consensus CDS
      CCDS49677.1
      UniProtKB/Swiss-Prot
      E9Q7T7
      Related
      ENSMUSP00000072682.6, ENSMUST00000072910.6
      Conserved Domains (6) summary
      smart00013
      Location:32 → 64
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:674 → 722
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:411 → 602
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:426 → 449
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:642 → 675
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:158 → 217
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      81570366..81581564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520742.5 → XP_006520805.1  chondroadherin-like protein isoform X1

      Conserved Domains (6) summary
      PRK15370
      Location:32 → 322
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      smart00013
      Location:405 → 439
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:685 → 733
      LRRCT; Leucine rich repeat C-terminal domain
      COG4886
      Location:507 → 687
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:437 → 460
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:169 → 228
      LRR_8; Leucine rich repeat

    2. XM_030248458.2 → XP_030104318.1  chondroadherin-like protein isoform X2

      Conserved Domains (5) summary
      PRK15370
      Location:21 → 311
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      smart00013
      Location:394 → 428
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:465 → 625
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:63 → 86
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:158 → 217
      LRR_8; Leucine rich repeat

    RNA

    1. XR_383996.5 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_020216.1: Suppressed sequence

      Description
      NG_020216.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.

    2. NG_020217.1: Suppressed sequence

      Description
      NG_020217.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q7T7.1 GenPept UniProtKB/Swiss-Prot:E9Q7T7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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