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    TRIM71 tripartite motif containing 71 [ Homo sapiens (human) ]

    Gene ID: 131405, updated on 9-Dec-2024

    Summary

    Official Symbol
    TRIM71provided by HGNC
    Official Full Name
    tripartite motif containing 71provided by HGNC
    Primary source
    HGNC:HGNC:32669
    See related
    Ensembl:ENSG00000206557 MIM:618570; AllianceGenome:HGNC:32669
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HYC4; LIN41; HYDCC1; LIN-41
    Summary
    The protein encoded by this gene is an E3 ubiquitin-protein ligase that binds with miRNAs and maintains the growth and upkeep of embryonic stem cells. This gene also is involved in the G1-S phase transition of the cell cycle. [provided by RefSeq, Dec 2015]
    Expression
    Biased expression in testis (RPKM 4.2), kidney (RPKM 0.7) and 1 other tissue See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TRIM71 in Genome Data Viewer
    Location:
    3p22.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (32817997..32897824)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (32816172..32895937)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (32859489..32939316)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene CCR4-NOT transcription complex subunit 10 Neighboring gene Sharpr-MPRA regulatory region 10112 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:32821346-32822066 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:32822067-32822788 Neighboring gene SUGT1 pseudogene 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:32822789-32823508 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:32828513-32828689 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:32841241-32842000 Neighboring gene Sharpr-MPRA regulatory region 2511 Neighboring gene ribosomal protein L23a pseudogene 43 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:32859949-32860530 Neighboring gene MPRA-validated peak4592 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:32877349-32877906 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:32878590-32879187 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:32879188-32879784 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:32880383-32880978 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:32885158-32885753 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:32888797-32889377 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:32895307-32895816 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:32897845-32898520 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:32902307-32902911 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:32905556-32906320 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:32910977-32911780 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:32914193-32914996 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:32944496-32944651 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14180 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14179 Neighboring gene MPRA-validated peak4594 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr3:32978284-32978481 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:32981295-32981797 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14181 Neighboring gene uncharacterized LOC107986072 Neighboring gene C-C motif chemokine receptor 4 Neighboring gene galactosidase beta 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Hydrocephalus, congenital communicating, 1
    MedGen: C5231454 OMIM: 618667 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables miRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables miRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables translation repressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in G1/S transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fibroblast growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in miRNA-mediated gene silencing by inhibition of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neural tube closure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neural tube development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of miRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_positive_effect post-transcriptional regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein autoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of neural precursor cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in stem cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in P-body ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM71
    Names
    RING-type E3 ubiquitin transferase TRIM71
    abnormal cell LINeage LIN-41
    homolog of C. elegans Lin-41
    protein lin-41 homolog
    tripartite motif containing 71, E3 ubiquitin protein ligase
    tripartite motif-containing protein 71
    NP_001034200.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039111.3NP_001034200.1  E3 ubiquitin-protein ligase TRIM71

      See identical proteins and their annotated locations for NP_001034200.1

      Status: REVIEWED

      Source sequence(s)
      AC139452, AW196612, DQ232881
      Consensus CDS
      CCDS43060.1
      UniProtKB/Swiss-Prot
      Q2Q1W2
      Related
      ENSP00000373272.3, ENST00000383763.6
      Conserved Domains (7) summary
      smart00502
      Location:314444
      BBC; B-Box C-terminal domain
      cd14954
      Location:584868
      NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins
      sd00039
      Location:704740
      7WD40; WD40 repeat [structural motif]
      cd16589
      Location:897
      RING-HC_TRIM71_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 71 (TRIM71) and similar proteins
      cd19796
      Location:277322
      Bbox2_TRIM71_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 71 (TRIM71) and similar proteins
      cd19812
      Location:198240
      Bbox1_TRIM71_C-VII; B-box-type 1 zinc finger found in tripartite motif-containing protein 71 (TRIM71) and similar proteins
      pfam00630
      Location:482577
      Filamin; Filamin/ABP280 repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      32817997..32897824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791770.1 Reference GRCh38.p14 PATCHES

      Range
      186223..266050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      32816172..32895937
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)