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    Zfand6 zinc finger, AN1-type domain 6 [ Mus musculus (house mouse) ]

    Gene ID: 65098, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfand6provided by MGI
    Official Full Name
    zinc finger, AN1-type domain 6provided by MGI
    Primary source
    MGI:MGI:1929510
    See related
    Ensembl:ENSMUSG00000030629 AllianceGenome:MGI:1929510
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Awp1; Za20d3; 3110005P07Rik
    Summary
    Enables polyubiquitin modification-dependent protein binding activity. Involved in protein targeting to peroxisome. Acts upstream of or within signal transduction. Predicted to be located in cytoplasm. Is expressed in several structures, including central nervous system; lower urinary tract; and retina. Orthologous to human ZFAND6 (zinc finger AN1-type containing 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 49.8), bladder adult (RPKM 34.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfand6 in Genome Data Viewer
    Location:
    7 D3; 7 48.36 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (84264253..84339224, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (84615045..84690016, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cortexin domain containing 1 Neighboring gene STARR-positive B cell enhancer mm9_chr7:91742914-91743215 Neighboring gene STARR-seq mESC enhancer starr_19439 Neighboring gene fumarylacetoacetate hydrolase Neighboring gene STARR-positive B cell enhancer ABC_E2830 Neighboring gene RIKEN cDNA 2610206C17 gene Neighboring gene STARR-positive B cell enhancer mm9_chr7:91838324-91838625 Neighboring gene STARR-seq mESC enhancer starr_19440 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:91898346-91898547 Neighboring gene STARR-positive B cell enhancer mm9_chr7:91898675-91898976 Neighboring gene transformation related protein 63 regulated like, pseudogene 1 Neighboring gene predicted gene, 57784 Neighboring gene predicted gene, 53362

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase. Miyata N, et al. Traffic, 2012 Jan. PMID 21980954
    2. Cloning and characterization of AWP1, a novel protein that associates with serine/threonine kinase PRK1 in vivo. Duan W, et al. Gene, 2000 Oct 3. PMID 11054541
    3. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
    4. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AWP1 is a novel cofactor of Pex6 involved in the regulation of Pex5 export during peroxisome biogenesis.
      Title: AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to tumor necrosis factor ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein targeting to peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within signal transduction IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    AN1-type zinc finger protein 6
    Names
    associated with PRK1 protein
    associated with Prkcl1
    zinc finger A20 domain-containing protein 3
    zinc finger, A20 domain containing 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360577.1 → NP_001347506.1  AN1-type zinc finger protein 6 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1-6 all encode the same isoform (a).
      Source sequence(s)
      AC132619, AV471887, CJ088967
      Consensus CDS
      CCDS21419.1
      UniProtKB/Swiss-Prot
      Q9DCH6, Q9ER79
      UniProtKB/TrEMBL
      A0A140LIM2
      Related
      ENSMUSP00000146878.2, ENSMUST00000209165.2
      Conserved Domains (2) summary
      smart00154
      Location:164 → 201
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    2. NM_001360578.1 → NP_001347507.1  AN1-type zinc finger protein 6 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
      Source sequence(s)
      AC132619
      Consensus CDS
      CCDS21419.1
      UniProtKB/Swiss-Prot
      Q9DCH6, Q9ER79
      UniProtKB/TrEMBL
      A0A140LIM2
      Related
      ENSMUSP00000146518.2, ENSMUST00000209117.2
      Conserved Domains (2) summary
      smart00154
      Location:164 → 201
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    3. NM_001360579.1 → NP_001347508.1  AN1-type zinc finger protein 6 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
      Source sequence(s)
      AC132619
      Consensus CDS
      CCDS21419.1
      UniProtKB/Swiss-Prot
      Q9DCH6, Q9ER79
      UniProtKB/TrEMBL
      A0A140LIM2
      Related
      ENSMUSP00000147192.2, ENSMUST00000208782.2
      Conserved Domains (2) summary
      smart00154
      Location:164 → 201
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    4. NM_001360580.1 → NP_001347509.1  AN1-type zinc finger protein 6 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
      Source sequence(s)
      AC132619
      Consensus CDS
      CCDS21419.1
      UniProtKB/Swiss-Prot
      Q9DCH6, Q9ER79
      UniProtKB/TrEMBL
      A0A140LIM2
      Related
      ENSMUSP00000135968.2, ENSMUST00000178385.9
      Conserved Domains (2) summary
      smart00154
      Location:164 → 201
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    5. NM_001360581.1 → NP_001347510.1  AN1-type zinc finger protein 6 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
      Source sequence(s)
      AC132619, BY307690
      Consensus CDS
      CCDS21419.1
      UniProtKB/Swiss-Prot
      Q9DCH6, Q9ER79
      UniProtKB/TrEMBL
      A0A140LIM2
      Related
      ENSMUSP00000146682.2, ENSMUST00000207865.2
      Conserved Domains (2) summary
      smart00154
      Location:164 → 201
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    6. NM_001360582.1 → NP_001347511.1  AN1-type zinc finger protein 6 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
      Source sequence(s)
      AC132619, CJ088967
      UniProtKB/TrEMBL
      A0A140LIM2
      Conserved Domains (2) summary
      smart00154
      Location:163 → 200
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    7. NM_022985.7 → NP_075361.2  AN1-type zinc finger protein 6 isoform a

      See identical proteins and their annotated locations for NP_075361.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
      Source sequence(s)
      AC132619
      Consensus CDS
      CCDS21419.1
      UniProtKB/Swiss-Prot
      Q9DCH6, Q9ER79
      UniProtKB/TrEMBL
      A0A140LIM2
      Related
      ENSMUSP00000069228.3, ENSMUST00000069537.3
      Conserved Domains (2) summary
      smart00154
      Location:164 → 201
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      84264253..84339224 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508110.3 → XP_006508173.1  AN1-type zinc finger protein 6 isoform X3

      See identical proteins and their annotated locations for XP_006508173.1

      UniProtKB/TrEMBL
      A0A140LIM2
      Conserved Domains (2) summary
      smart00154
      Location:149 → 186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    2. XM_030242873.2 → XP_030098733.1  AN1-type zinc finger protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A140LIM2
      Conserved Domains (2) summary
      smart00154
      Location:163 → 200
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    3. XM_030242871.2 → XP_030098731.1  AN1-type zinc finger protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A140LIM2
      Conserved Domains (2) summary
      smart00154
      Location:163 → 200
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    4. XM_036153333.1 → XP_036009226.1  AN1-type zinc finger protein 6 isoform X3

      UniProtKB/TrEMBL
      A0A140LIM2
      Conserved Domains (2) summary
      smart00154
      Location:149 → 186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    5. XM_030242867.2 → XP_030098727.1  AN1-type zinc finger protein 6 isoform X1

      UniProtKB/Swiss-Prot
      Q9DCH6, Q9ER79
      UniProtKB/TrEMBL
      A0A140LIM2
      Conserved Domains (2) summary
      smart00154
      Location:164 → 201
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    6. XM_030242866.2 → XP_030098726.1  AN1-type zinc finger protein 6 isoform X1

      UniProtKB/Swiss-Prot
      Q9DCH6, Q9ER79
      UniProtKB/TrEMBL
      A0A140LIM2
      Conserved Domains (2) summary
      smart00154
      Location:164 → 201
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    7. XM_030242870.2 → XP_030098730.1  AN1-type zinc finger protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A140LIM2
      Conserved Domains (2) summary
      smart00154
      Location:163 → 200
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    8. XM_030242875.1 → XP_030098735.1  AN1-type zinc finger protein 6 isoform X3

      UniProtKB/TrEMBL
      A0A140LIM2
      Conserved Domains (2) summary
      smart00154
      Location:149 → 186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    9. XM_030242872.2 → XP_030098732.1  AN1-type zinc finger protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A140LIM2
      Conserved Domains (2) summary
      smart00154
      Location:163 → 200
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    10. XM_030242876.2 → XP_030098736.1  AN1-type zinc finger protein 6 isoform X3

      UniProtKB/TrEMBL
      A0A140LIM2
      Conserved Domains (2) summary
      smart00154
      Location:149 → 186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    11. XM_030242869.2 → XP_030098729.1  AN1-type zinc finger protein 6 isoform X1

      UniProtKB/Swiss-Prot
      Q9DCH6, Q9ER79
      UniProtKB/TrEMBL
      A0A140LIM2
      Conserved Domains (2) summary
      smart00154
      Location:164 → 201
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    12. XM_036153331.1 → XP_036009224.1  AN1-type zinc finger protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A140LIM2
      Conserved Domains (2) summary
      smart00154
      Location:163 → 200
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    13. XM_036153330.1 → XP_036009223.1  AN1-type zinc finger protein 6 isoform X1

      UniProtKB/Swiss-Prot
      Q9DCH6, Q9ER79
      UniProtKB/TrEMBL
      A0A140LIM2
      Conserved Domains (2) summary
      smart00154
      Location:164 → 201
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    14. XM_030242868.1 → XP_030098728.1  AN1-type zinc finger protein 6 isoform X1

      UniProtKB/Swiss-Prot
      Q9DCH6, Q9ER79
      UniProtKB/TrEMBL
      A0A140LIM2
      Conserved Domains (2) summary
      smart00154
      Location:164 → 201
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    15. XM_030242874.1 → XP_030098734.1  AN1-type zinc finger protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A140LIM2
      Conserved Domains (2) summary
      smart00154
      Location:163 → 200
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger

    16. XM_030242877.1 → XP_030098737.1  AN1-type zinc finger protein 6 isoform X3

      UniProtKB/TrEMBL
      A0A140LIM2
      Conserved Domains (2) summary
      smart00154
      Location:149 → 186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:12 → 34
      zf-A20; A20-like zinc finger
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCH6.1 GenPept UniProtKB/Swiss-Prot:Q9DCH6

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