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    ZFP69B ZFP69 zinc finger protein B [ Homo sapiens (human) ]

    Gene ID: 65243, updated on 9-Dec-2024

    Summary

    Official Symbol
    ZFP69Bprovided by HGNC
    Official Full Name
    ZFP69 zinc finger protein Bprovided by HGNC
    Primary source
    HGNC:HGNC:28053
    See related
    Ensembl:ENSG00000187801 AllianceGenome:HGNC:28053
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF643; ZSCAN54B; ZKSCAN23B
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in Golgi organization. Located in nucleolus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 1.6), appendix (RPKM 1.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZFP69B in Genome Data Viewer
    Location:
    1p34.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (40450064..40463715)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (40319624..40333275)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40915736..40929387)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21 pseudogene 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 843 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 844 Neighboring gene small ArfGAP2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 726 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 727 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:40839657-40840156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 845 Neighboring gene Sharpr-MPRA regulatory region 11139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 728 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:40916242-40917441 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 729 Neighboring gene ZFP69 zinc finger protein Neighboring gene EXO5 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 846 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 847 Neighboring gene exonuclease 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • FLJ34293

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger protein 69 homolog B
    Names
    novel zinc finger protein
    zinc finger protein 643
    zinc finger protein ZFP69B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001369565.1NP_001356494.1  zinc finger protein 69 homolog B

      Status: VALIDATED

      Source sequence(s)
      AL031985
      Consensus CDS
      CCDS452.2
      UniProtKB/Swiss-Prot
      Q5QPL4, Q9UJL9
      Related
      ENSP00000399664.2, ENST00000411995.6
      Conserved Domains (5) summary
      smart00349
      Location:74133
      KRAB; krueppel associated box
      COG5048
      Location:221429
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:309329
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:433458
      zf-H2C2_2; Zinc-finger double domain
      cl02605
      Location:240
      SCAN; SCAN oligomerization domain
    2. NM_023070.3NP_075558.2  zinc finger protein 69 homolog B

      See identical proteins and their annotated locations for NP_075558.2

      Status: VALIDATED

      Source sequence(s)
      AL031985, BC017498, CN256362
      Consensus CDS
      CCDS452.2
      UniProtKB/Swiss-Prot
      Q5QPL4, Q9UJL9
      Related
      ENSP00000354547.4, ENST00000361584.5
      Conserved Domains (5) summary
      smart00349
      Location:74133
      KRAB; krueppel associated box
      COG5048
      Location:221429
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:309329
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:433458
      zf-H2C2_2; Zinc-finger double domain
      cl02605
      Location:240
      SCAN; SCAN oligomerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      40450064..40463715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005271136.2XP_005271193.1  zinc finger protein 69 homolog B isoform X1

      Related
      ENST00000469416.1
      Conserved Domains (5) summary
      smart00349
      Location:74134
      KRAB; krueppel associated box
      COG5048
      Location:194430
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:310330
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:434459
      zf-H2C2_2; Zinc-finger double domain
      cl02605
      Location:240
      SCAN; SCAN oligomerization domain
    2. XM_017002147.2XP_016857636.1  zinc finger protein 69 homolog B isoform X1

      Conserved Domains (5) summary
      smart00349
      Location:74134
      KRAB; krueppel associated box
      COG5048
      Location:194430
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:310330
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:434459
      zf-H2C2_2; Zinc-finger double domain
      cl02605
      Location:240
      SCAN; SCAN oligomerization domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      40319624..40333275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338413.1XP_054194388.1  zinc finger protein 69 homolog B isoform X1

    2. XM_054338414.1XP_054194389.1  zinc finger protein 69 homolog B isoform X1