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    TESMIN testis expressed metallothionein like protein [ Homo sapiens (human) ]

    Gene ID: 9633, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TESMINprovided by HGNC
    Official Full Name
    testis expressed metallothionein like proteinprovided by HGNC
    Primary source
    HGNC:HGNC:7446
    See related
    Ensembl:ENSG00000132749 MIM:604374; AllianceGenome:HGNC:7446
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MTL5; MTLT; CXCDC2
    Summary
    Metallothionein proteins are highly conserved low-molecular-weight cysteine-rich proteins that are induced by and bind to heavy metal ions and have no enzymatic activity. They may play a central role in the regulation of cell growth and differentiation and are involved in spermatogenesis. This gene encodes a metallothionein-like protein which has been shown to be expressed differentially in mouse testis and ovary. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in testis (RPKM 13.9), bone marrow (RPKM 1.4) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TESMIN in Genome Data Viewer
    Location:
    11q13.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (68704796..68751520, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (68710920..68757642, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (68474908..68518988, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase 6 regulatory subunit 3 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68278329-68278907 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68278908-68279485 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr11:68307752-68308457 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68310718-68311218 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68311219-68311719 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68351250-68351750 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:68370649-68370853 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68376961-68377462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68377463-68377962 Neighboring gene NANOG hESC enhancer GRCh37_chr11:68390073-68390603 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:68399697-68400286 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:68400287-68400875 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:68400876-68401464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68419596-68420268 Neighboring gene uncharacterized LOC107984343 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68450731-68451406 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68452083-68452758 Neighboring gene Sharpr-MPRA regulatory region 1260 Neighboring gene NANOG hESC enhancer GRCh37_chr11:68462220-68462721 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68474187-68474945 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68479758-68480258 Neighboring gene galanin and GMAP prepropeptide Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3678 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68518115-68519100 Neighboring gene uncharacterized LOC124902699 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68531008-68531810 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:68549035-68550234 Neighboring gene carnitine palmitoyltransferase 1A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68565881-68566380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5141 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3679 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3682 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3683 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68609778-68610303 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5144 Neighboring gene uncharacterized LOC124902700 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3685

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Clinical Significance and Functional Insights of Tesmin in Hepatocellular Carcinoma. Cao L, et al. Genet Res (Camb), 2024. PMID 38283987, Free PMC Article
    2. Metallothionein-like 5 expression is correlated with poor prognosis and promotes proliferation of cervical squamous cell carcinoma. Huang Y, et al. Bioengineered, 2022 Mar. PMID 35249447, Free PMC Article
    3. Germ cell-specific nucleocytoplasmic shuttling protein, tesmin, responsive to heavy metal stress in mouse testes. Matsuura T, et al. J Inorg Biochem, 2002 Jan 15. PMID 11803038
    4. A novel testis-specific metallothionein-like protein, tesmin, is an early marker of male germ cell differentiation. Sugihara T, et al. Genomics, 1999 Apr 1. PMID 10191092
    5. Native tesmin is a 60-kilodalton protein that undergoes dynamic changes in its localization during spermatogenesis in mice. Sutou S, et al. Biol Reprod, 2003 May. PMID 12606435

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical Significance and Functional Insights of Tesmin in Hepatocellular Carcinoma.
      Title: Clinical Significance and Functional Insights of Tesmin in Hepatocellular Carcinoma.
    2. Metallothionein-like 5 expression is correlated with poor prognosis and promotes proliferation of cervical squamous cell carcinoma.
      Title: Metallothionein-like 5 expression is correlated with poor prognosis and promotes proliferation of cervical squamous cell carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular monoatomic cation homeostasis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in male meiotic nuclear division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to metal ion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in male germ cell nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tesmin
    Names
    CXC domain containing 2
    metallothionein-like 5, testis-specific (tesmin)
    testis-specific metallothionein-like protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039656.1 → NP_001034745.1  tesmin isoform b

      See identical proteins and their annotated locations for NP_001034745.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter at the C-terminus compared to isoform a.
      Source sequence(s)
      AP003096, BC027593, BM790577
      Consensus CDS
      CCDS44661.1
      UniProtKB/Swiss-Prot
      Q9Y4I5
      Related
      ENSP00000440968.1, ENST00000544963.1

    2. NM_004923.3 → NP_004914.2  tesmin isoform a

      See identical proteins and their annotated locations for NP_004914.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      BC064579, BM790577
      Consensus CDS
      CCDS8184.1
      UniProtKB/Swiss-Prot
      A8K8J3, Q4G182, Q6P2E2, Q8NCC8, Q9Y4I5
      Related
      ENSP00000255087.5, ENST00000255087.10
      Conserved Domains (1) summary
      pfam03638
      Location:367 → 404
      TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      68704796..68751520 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018588.2 → XP_016874077.1  tesmin isoform X2

    2. XM_011545402.2 → XP_011543704.1  tesmin isoform X1

      See identical proteins and their annotated locations for XP_011543704.1

      Conserved Domains (1) summary
      pfam03638
      Location:367 → 404
      TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain

    3. XM_047427921.1 → XP_047283877.1  tesmin isoform X3

    4. XM_047427924.1 → XP_047283880.1  tesmin isoform X6

    5. XM_047427923.1 → XP_047283879.1  tesmin isoform X5

    6. XM_047427922.1 → XP_047283878.1  tesmin isoform X4

    RNA

    1. XR_007062529.1 RNA Sequence

    2. XR_007062530.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      68710920..68757642 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370606.1 → XP_054226581.1  tesmin isoform X2

    2. XM_054370605.1 → XP_054226580.1  tesmin isoform X1

    3. XM_054370607.1 → XP_054226582.1  tesmin isoform X3

    4. XM_054370610.1 → XP_054226585.1  tesmin isoform X6

    5. XM_054370609.1 → XP_054226584.1  tesmin isoform X5

    6. XM_054370608.1 → XP_054226583.1  tesmin isoform X4

    RNA

    1. XR_008488496.1 RNA Sequence

    2. XR_008488497.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y4I5.2 GenPept UniProtKB/Swiss-Prot:Q9Y4I5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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