Replication interactions
Interaction |
Pubs |
Knockdown of hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells |
PubMed
|
Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Nef
|
nef
|
HIV-1 Nef co-localizes with CXCR4, AIP4, NEDD4, CD63/LAMP-1-positive vesicles, and HRS/VPS27-positive ESCRT-0 structures in HeLa cells |
PubMed
|
Pr55(Gag)
|
gag
|
Overexpression of the C-terminal fragment of HRS (residues 391-777) or HRS mutants lacking either the N-terminal FYVE domain (residues 215-290) or the PSAP (residues 348-351) motif efficiently inhibit HIV-1 Gag particle production |
PubMed
|
Vpu
|
vpu
|
Vpu interacts with HGS (HRS) via the HGS double-ubiquitin interaction motif, indicating this motif is the direct binding site for Vpu or ubiquitination of cargo mediates Vpu/HGS interaction or by factors associated in the degradation pathway |
PubMed
|
|
vpu
|
Physiological levels of Vpu requires the core ESCRT pathway (TSG1010 and UBAP1) and HGA (HRS) for Vpu-mediated BST-2 (tetherin) degradation but does NOT require these proteins for counteraction of BST2 (tetherin's) physical antiviral activity |
PubMed
|
|
vpu
|
HRS, an ESCRT-0 complex component, is required for the Vpu-induced downregulation of BST-2, indicating that Vpu-induced BST-2 degradation involves the ESCRT/MVB pathway |
PubMed
|
|
vpu
|
HRS interacts with both HIV-1 Vpu and tetherin by co-precipitation analysis |
PubMed
|
Go to the HIV-1, Human Interaction Database