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    F2rl2 coagulation factor II thrombin receptor like 2 [ Mus musculus (house mouse) ]

    Gene ID: 14064, updated on 9-Dec-2024

    Summary

    Official Symbol
    F2rl2provided by MGI
    Official Full Name
    coagulation factor II thrombin receptor like 2provided by MGI
    Primary source
    MGI:MGI:1298208
    See related
    Ensembl:ENSMUSG00000021675 AllianceGenome:MGI:1298208
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PAR3; F730031A08
    Summary
    Enables proteinase-activated receptor activity and receptor ligand activity. Involved in G protein-coupled receptor signaling pathway; ligand-gated ion channel signaling pathway; and positive regulation of insulin secretion. Located in apical plasma membrane. Is expressed in several structures, including central nervous system; liver; retina; skin; and spleen. Orthologous to human F2RL2 (coagulation factor II thrombin receptor like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver E14.5 (RPKM 6.6), spleen adult (RPKM 5.4) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See F2rl2 in Genome Data Viewer
    Location:
    13 D1; 13 50.38 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (95833428..95839276)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (95696920..95702768)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene IQ motif containing GTPase activating protein 2 Neighboring gene predicted gene, 33074 Neighboring gene predicted gene, 48745 Neighboring gene predicted gene, 52062 Neighboring gene STARR-seq mESC enhancer starr_35329 Neighboring gene predicted gene, 32702

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables proteinase-activated receptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables thrombin-activated receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    proteinase-activated receptor 3
    Names
    PAR-3
    Proteinase activated receptor 3 precursor (PAR-3) (Thrombin receptor-like 2) (Coagulation factor II receptor-like 2)
    coagulation factor II receptor-like 2
    protease-activated receptor 3
    thrombin receptor-like 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010170.4NP_034300.3  proteinase-activated receptor 3 precursor

      See identical proteins and their annotated locations for NP_034300.3

      Status: VALIDATED

      Source sequence(s)
      AC171003
      Consensus CDS
      CCDS26702.1
      UniProtKB/Swiss-Prot
      B9EIT2, O08675, Q3UXV3
      UniProtKB/TrEMBL
      Q8BJB7
      Related
      ENSMUSP00000022182.5, ENSMUST00000022182.5
      Conserved Domains (2) summary
      pfam00001
      Location:112357
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:104312
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      95833428..95839276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)