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    Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic [ Mus musculus (house mouse) ]

    Gene ID: 18534, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pck1provided by MGI
    Official Full Name
    phosphoenolpyruvate carboxykinase 1, cytosolicprovided by MGI
    Primary source
    MGI:MGI:97501
    See related
    Ensembl:ENSMUSG00000027513 AllianceGenome:MGI:97501
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PEPCK; Pck-1; PEPCK-C
    Summary
    Enables phosphoenolpyruvate carboxykinase (GTP) activity. Involved in several processes, including gluconeogenesis; glyceraldehyde-3-phosphate biosynthetic process; and positive regulation of memory T cell differentiation. Acts upstream of or within several processes, including cellular response to potassium ion starvation; glycerol biosynthetic process from pyruvate; and positive regulation of transcription by RNA polymerase II. Is active in cytosol. Is expressed in several structures, including alimentary system; brown fat; cerebral cortex; liver; and urinary system. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human PCK1 (phosphoenolpyruvate carboxykinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney adult (RPKM 295.2), liver adult (RPKM 158.6) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pck1 in Genome Data Viewer
    Location:
    2 H3; 2 95.79 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (172994866..173001067)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (173153073..173159274)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 40011 Neighboring gene CCCTC-binding factor like, opposite strand Neighboring gene STARR-seq mESC enhancer starr_06610 Neighboring gene predicted gene, 36691 Neighboring gene predicted gene, 36749 Neighboring gene STARR-positive B cell enhancer ABC_E9076 Neighboring gene STARR-seq mESC enhancer starr_06613 Neighboring gene Z-DNA binding protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:173055154-173055337 Neighboring gene STARR-seq mESC enhancer starr_06615 Neighboring gene prostate transmembrane protein, androgen induced 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables carboxylic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables carboxylic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables manganese ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleoside diphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoenolpyruvate carboxykinase (GTP) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphoenolpyruvate carboxykinase (GTP) activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables phosphoenolpyruvate carboxykinase (GTP) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoenolpyruvate carboxykinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables phosphoenolpyruvate carboxykinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity (using GTP as donor) ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity (using GTP as donor) ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cellular hyperosmotic salinity response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular hypotonic salinity response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to dexamethasone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to fructose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucagon stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucose stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to glucose stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to insulin stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to interleukin-1 IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to phorbol 13-acetate 12-myristate IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to potassium ion starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to raffinose IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within gluconeogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in gluconeogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glyceraldehyde-3-phosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glycerol biosynthetic process from pyruvate IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within glycerol biosynthetic process from pyruvate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glycerol biosynthetic process from pyruvate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hepatocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in oxaloacetate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in oxaloacetate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in oxaloacetate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of memory T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in propionate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of lipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to activity IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to insulin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to interleukin-6 IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to methionine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tricarboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tricarboxylic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    phosphoenolpyruvate carboxykinase, cytosolic [GTP]
    Names
    phosphoenolpyruvate carboxykinase, cytosolic
    phosphoenolpyruvate carboxylase
    serine-protein kinase PCK1
    NP_035174.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011044.3NP_035174.1  phosphoenolpyruvate carboxykinase, cytosolic [GTP]

      Status: VALIDATED

      Source sequence(s)
      AL837509
      Consensus CDS
      CCDS17141.1
      UniProtKB/Swiss-Prot
      Q3UEH3, Q9Z2V4
      UniProtKB/TrEMBL
      Q8BSX3, Q8CI37
      Related
      ENSMUSP00000029017.6, ENSMUST00000029017.6
      Conserved Domains (1) summary
      cd00819
      Location:27615
      PEPCK_GTP; Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      172994866..173001067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)